Deformable underlayer for stent

• US 7,938,855 B2
• Filed: 11/02/2007
• Issued: 05/10/2011
• Est. Priority Date: 11/02/2007
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Sorenson, Shawn, Gregorich, Daniel J.
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US11/934,391
• Publication Number:
  US 20090118820A1
• Time in Patent Office: 1,285 Days
• Field of Search: 623 142- 148, 424/426
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque

Abstract

An endoprosthesis includes a brittle layer, e.g. a ceramic and an underlayer to accommodate dimensional changes as the endoprosthesis is flexed.

Claims

1. An endoprosthesis, comprising:

a stent wall including

a stent body,

a ceramic coating having a defined grain or globular morphology, and

an underlayer between the stent body and the ceramic coating, the underlayer comprising a polymer and being more easily deformed than the ceramic coating and the stent body and having a thickness selected in coordination with deformability of the underlayer and degree of deformity of the stent body to be accommodated due to expansion of the stent body during use, such that the ceramic coating remains substantially dimensionally constant during expansion of the stent body.

2. The endoprosthesis of claim 1 wherein underlayer has a bulk modulus that is about 75% or less than the modulus of the stent body.

3. The endoprosthesis of claim 1 wherein the thickness of the underlayer is about 1% or less than the stent body and 200% to 1% of the thickness of the ceramic.

4. The endoprosthesis of claim 1 wherein the underlayer is comprises a metal.

5. The endoprosthesis of claim 1 wherein the underlayer is more dense than the stent body.

6. The endoprosthesis of claim 1 wherein the ceramic coating forms a relatively continuous layer having a globular morphology.

7. The endoprosthesis of claim 1 wherein the ceramic coating has a defined grain morphology.

8. The endoprosthesis of claim 1 wherein the ceramic coating is in a particulate form.

9. The endoprosthesis of claim 1 wherein the underlayer includes comprises a drug.

10. The endoprosthesis of claim 1 wherein the ceramic coating is iridium oxide.

11. The endoprosthesis of claim 1 wherein the underlayer includes comprises a higher density radiopaque component.

12. The endoprosthesis of claim 1 wherein the stent wall comprises an abluminal surface and an adluminal surface, and the ceramic coating and underlayer are on the abluminal surface only.

15. The endoprosthesis of claim 1 wherein the ceramic coating is directly atop the underlayer and the underlayer is directly atop the stent body.

16. The endoprosthesis of claim 1 wherein the stent body is stainless steel.

13. An endoprosthesis, comprising:

a stent wall including

a stent body,

a ceramic coating having a defined grain or globular morphology, and

an underlayer between the stent body and the ceramic coating, the underlayer being more easily deformed than the ceramic coating and the stent body and having a thickness selected in coordination with deformability of the underlayer and degree of deformity of the stent body to be accommodated due to expansion of the stent body during use, such that the ceramic coating remains substantially dimensionally constant during expansion of the stent body, and

wherein the stent wall defines an abluminal surface and an adluminal surface, and the ceramic coating and underlayer are on the abluminal surface and on the adluminal surface.

14. The endoprosthesis of claim 13 wherein the underlayer on the abluminal surface and the underlayer on the adluminal surface have different thicknesses or compositions.

17. An endoprosthesis, comprising:

a stent wall including

a stent body formed of a metal,

a ceramic coating formed of an oxide and having a globular morphology, and

an underlayer formed of another metal between the stent body and the ceramic coating, the underlayer having a bulk modulus that is about 75% or less than the modulus of the stent body and having a thickness selected in coordination with deformability of the underlayer and degree of deformity of the stent body to be accommodated due to expansion of the stent body during use, the thickness of the underlayer being less than the thickness of the ceramic coating and the underlayer having a density greater than the density of the stent body, such that the ceramic coating remains substantially dimensionally constant during expansion of the stent body.

18. An endoprosthesis, comprising:

a stent wall including

a stent body,

a ceramic coating having a defined grain or globular morphology, and

an underlayer comprising a polymer, the underlayer being between the stent body and the ceramic coating and being more easily deformed than the ceramic coating and the stent body.

19. An endoprosthesis, comprising:

a stent wall having an abluminal surface and an adluminal surface, the stent wall including

a stent body,

a ceramic coating having a defined grain or globular morphology, and

an underlayer between the stent body and the ceramic coating, the underlayer being more easily deformed than the ceramic coating and the stent body, the ceramic coating and the underlayer being on the abluminal surface and on the adluminal surface, and the ceramic coating on the abluminal surface and the ceramic coating on the adluminal surface have different morphologies or compositions.