Antagonizing signal transduction in dorsal root ganglion cells in a subject with IL-31 antagonists
First Claim
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1. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject in need thereof, comprising contacting an antibody or a fragment thereof with the dorsal root ganglion cells wherein the antibody or antibody fragment binds Interleukin 31 (IL-31) and whereby the signal transduction is inhibited.
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Abstract
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
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28 Claims
- 1. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject in need thereof, comprising contacting an antibody or a fragment thereof with the dorsal root ganglion cells wherein the antibody or antibody fragment binds Interleukin 31 (IL-31) and whereby the signal transduction is inhibited.
- 10. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject, comprising administering an antibody or antibody fragment to the dorsal root ganglion cells wherein the antibody binds Interleukin 31 (IL-31) and whereby the signal transduction is inhibited.
- 19. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject in need thereof, comprising admixing a receptor with the dorsal root ganglion cells wherein the receptor binds Interleukin 31 (IL-31) and whereby the signal transduction is inhibited.
- 24. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject in need thereof, comprising administering a receptor to the dorsal root ganglion cells wherein the receptor binds Interleukin 31 (IL-31) and whereby the signal transduction is inhibited.
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