RNAi inhibition of alpha-ENaC expression
First Claim
Patent Images
1. A composition comprising an iRNA agent comprising a first strand and a second strand, wherein:
- a. the sequence of the first strand is the sequence of SEQ ID NO;
143, and the sequence of the second strand is the sequence of SEQ ID NO;
144;
orb. the sequence of the first strand is the sequence of SEQ ID NO;
189, and the sequence of the second strand is the sequence of SEQ ID NO;
190;
orc. the sequence of the first strand is the sequence of SEQ ID NO;
447, and the sequence of the second strand is the sequence of SEQ ID NO;
448;
ord. the sequence of the first strand is the sequence of SEQ ID NO;
493, and the sequence of the second strand is the sequence of SEQ ID NO;
494.
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Abstract
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
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Citations
23 Claims
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1. A composition comprising an iRNA agent comprising a first strand and a second strand, wherein:
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a. the sequence of the first strand is the sequence of SEQ ID NO;
143, and the sequence of the second strand is the sequence of SEQ ID NO;
144;
orb. the sequence of the first strand is the sequence of SEQ ID NO;
189, and the sequence of the second strand is the sequence of SEQ ID NO;
190;
orc. the sequence of the first strand is the sequence of SEQ ID NO;
447, and the sequence of the second strand is the sequence of SEQ ID NO;
448;
ord. the sequence of the first strand is the sequence of SEQ ID NO;
493, and the sequence of the second strand is the sequence of SEQ ID NO;
494. - View Dependent Claims (2, 3, 4, 5, 10)
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6. A composition comprising an iRNA agent comprising a first strand and a second strand, wherein the sequences of the first strand and the second strand are the sequences of SEQ ID NOs:
- 143 and 144, respectively.
- View Dependent Claims (16, 17)
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7. A composition comprising an iRNA agent comprising a first strand and a second strand, wherein the sequences of the first strand and the second strand are the sequences of SEQ ID NOs:
- 189 and 190, respectively.
- View Dependent Claims (18, 19)
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8. A composition comprising an iRNA agent comprising a first strand and a second strand, wherein the sequences of the first strand the second strand are the sequences of SEQ ID NOs:
- 447 and 448, respectively.
- View Dependent Claims (20, 21)
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9. A composition comprising an iRNA agent comprising a first strand and a second strand, wherein the sequences of the first strand the second strand are the sequences of SEQ ID NOs:
- 493 and 494, respectively.
- View Dependent Claims (22, 23)
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11. A composition comprising an iRNA agent to alpha-ENaC, wherein the iRNA agent comprises a first strand and a second strand,
wherein the sequence of the first strand is a sequence selected from the group consisting of SEQ ID NO: - 143, SEQ ID NO;
189, SEQ ID NO;
447, and SEQ ID NO;
493, andwherein the sequence of the second strand is a sequence selected from the group consisting of SEQ ID NO;
144, SEQ ID NO;
190, SEQ ID NO;
448, and SEQ ID NO;
494,the composition further comprising an epithelial receptor ligand. - View Dependent Claims (12)
- 143, SEQ ID NO;
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13. A method of treating a human subject having a pathological state mediated at least in part by alpha-ENaC expression, the method comprising the step of administering to the subject a therapeutically effective amount of a composition comprising an iRNA agent comprising a first strand and a second strand, wherein:
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a. the sequence of the first strand is the sequence of SEQ ID NO;
143, and the sequence of the second strand is the sequence of SEQ ID NO;
144;
orb. the sequence of the first strand is the sequence of SEQ ID NO;
189, and the sequence of the second strand is the sequence of SEQ ID NO;
190);
orc. the sequence of the first strand is the sequence of SEQ ID NO;
447, and the sequence of the second strand is the sequence of SEQ ID NO;
448;
ord. the sequence of the first strand is the sequence of SEQ ID NO;
493, and the sequence of the second strand is the sequence of SEQ ID NO;
494. - View Dependent Claims (14, 15)
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Specification