Platelet derived growth factor (PDGF) nucleic acid ligand complexes
First Claim
1. A complex comprising a platelet derived growth factor (PDGF) nucleic acid ligand of SEQ ID NO:
- 146 and a non-immunogenic, high molecular weight compound, wherein N at positions 10 and 23 of SEQ ID NO;
146 is
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Abstract
This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same.
28 Citations
26 Claims
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1. A complex comprising a platelet derived growth factor (PDGF) nucleic acid ligand of SEQ ID NO:
- 146 and a non-immunogenic, high molecular weight compound, wherein N at positions 10 and 23 of SEQ ID NO;
146 is - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- 146 and a non-immunogenic, high molecular weight compound, wherein N at positions 10 and 23 of SEQ ID NO;
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11. A complex having the structure A-B-Y, wherein A is one or more polyalkylene glycols, B is a linker, and Y is a PDGF nucleic acid ligand of SEQ ID NO:
- 146, wherein N at positions 10 and 23 of SEQ ID NO;
146 is - View Dependent Claims (12, 13, 14, 15, 16)
- 146, wherein N at positions 10 and 23 of SEQ ID NO;
- 17. A complex comprising a non-immunogenic, high molecular weight compound and a platelet derived growth factor (PDGF) nucleic acid ligand, wherein the nucleic acid ligand has the structure:
Specification