Microprobe array structure and method for manufacturing the same

• US 7,941,201 B2
• Filed: 11/15/2006
• Issued: 05/10/2011
• Est. Priority Date: 06/09/2006
• Status: Expired due to Fees

• Current Assignee: National Chiao Tung University (Government of The Republic of China)
• Original Assignee: National Chiao Tung University (Government of The Republic of China)
• Inventors: Hung, Chen-Chun, Chang, Chih-Wei, Chiou, Jin-Chern
• Primary Examiner(s): Cohen; Lee S
• Application Number:
  US11/599,303
• Publication Number:
  US 20080009763A1
• Time in Patent Office: 1,637 Days
• Field of Search: 600/373, 600/393
• US Class Current: 600/373
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/25 Bioelectric electrodes therefor
• CPC Class Codes: A61B 5/257 using adhesive means, e.g. adhesive pads or tapes
• CPC Class Codes: A61B 5/262 Needle electrodes
• CPC Class Codes: A61B 5/266 containing electrolytes, conductive gels or pastes
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/685 Microneedles

Abstract

A microprobe array structure with self-stabilization capability and a method for manufacturing the same are proposed. The microprobe array structure is used to sense various biopotential signals, and is characterized in that the etching parameters are controlled during etching to manufacture a microprobe structure with a reduced bottom cross section so that the microprobe can be firmly stabilized in the skin tissue. Moreover, a conducting layer is formed on the microprobe to sense signals. A design of electric isolation between microprobes is also proposed. The microprobe array can therefore be used for the measurement of various biopotential signals, and can also be used as a stimulus.

Claims

1. A microprobe structure used to measure biopotential signals, said microprobe structure comprising:

an elongated tapering needle member having an increasing width in a first section integrally formed with a second section, said second section having an acute contour terminating at a point to define a tip portion; and

a conducting layer covering said needle member including said tip portion.

2. The microprobe structure as claimed in claim 1, wherein said tip portion is conical.

3. The microprobe structure as claimed in claim 1, wherein said tip portion can puncture the Stratum Corneum and Stratum Germinativum to allow said microprobe to get into said Stratum Germinativum and measure said biopotential signals.

4. The microprobe structure as claimed in claim 1, wherein said biopotential signals include electroencephalographic (EEG) signals, electrocardiographic (ECG) signals and electromyographic (EMG) signals.

5. The microprobe structure as claimed in claim 1, wherein the total length of said tip portion and said needle member is 250˜

450 micrometers.

6. The microprobe structure as claimed in claim 1, wherein a connection between said tip portion and a remaining portion of said needle member includes edges and corners to enhance a stabilization capability of said microprobe.

7. The microprobe structure as claimed in claim 1, wherein a ratio of a cross-sectional area at an interface between said tip portion and a remaining portion of said needle member and a bottom of said needle member is larger than 1.

8. The microprobe structure as claimed in claim 1, wherein the material of said conducting layer is polymer, thin film material or metal.

9. The microprobe structure as claimed in claim 1, wherein a bottom of said needle member is connected to a substrate and used as a sensing electrode that is connected to an external circuit and used to receive said measured biopotential signals.

10. The microprobe structure as claimed in claim 9, wherein the material of said substrate is silicon.

11. The microprobe structure as claimed in claim 9, wherein a plurality of said microprobes is disposed on said substrate to form a microprobe array.

12. The microprobe structure as claimed in claim 11, wherein said conducting layers of said microprobes are connected together to measure one of said biopotential signals.

13. The microprobe structure as claimed in claim 11, wherein said conducting layers of said microprobes are mutually isolated, and said microprobe array is used to measure a plurality of said biopotential signals.

14. The microprobe structure as claimed in claim 13, wherein each of said microprobes with mutually isolated conducting layers is used as a stimulus.

15. The microprobe structure as claimed in claim 14, wherein when said microprobe is used as a stimulus, a voltage or a current is conducted into said microprobe to electrify said microprobe or render pressure to the punctured location.

16. The microprobe structure as claimed in claim 11, wherein the shape of said microprobe array is a square, a circle, or an irregular shape.

17. The microprobe structure as claimed in claim 1, wherein the needle member including the tip portion is hollow.

18. A microprobe array structure used to measure biopotential signals, said microprobe array structure comprising:

a substrate; and

a plurality of microprobes each having an elongated tapering needle member having an increasing width in a first section integrally formed with a second section, said second section having an acute contour terminating at a point to define a tip portion, and a bottom of said needle member being connected to said substrate, wherein a conducting layer coats said needle member including said tip portion.

19. The microprobe array structure as claimed in claim 18, wherein said tip portion is conical.

20. The microprobe array structure as claimed in claim 18, wherein said tip portion can puncture the Stratum Corneum and Stratum Germinativum to allow said microprobe to get into said Stratum Germinativum and measure said biopotential signals.

21. The microprobe array structure as claimed in claim 18, wherein said biopotential signals include electroencephalographic (EEG) signals, electrocardiographic (ECG) signals and electromyographic (EMG) signals.

22. The microprobe array structure as claimed in claim 18, wherein the total length of said needle member including said tip portion is 250˜

450 micrometers.

23. The microprobe array structure as claimed in claim 18, wherein a connection between said tip portion and a remaining portion of said needle member includes edges and corners to enhance a stabilization capability of said microprobe.

24. The microprobe array structure as claimed in claim 18, wherein a ratio of a cross-sectional area at an interface between said tip portion and a remaining portion of said needle member and a bottom of said needle member is larger than 1.

25. The microprobe array structure as claimed in claim 18, wherein the material of said conducting layer is polymer, thin film material or metal.

26. The microprobe array structure as claimed in claim 18, wherein said substrate is used as a sensing electrode that is connected to an external circuit and used to receive said measured biopotential signals.

27. The microprobe array structure as claimed in claim 18, wherein the material of said substrate is silicon.

28. The microprobe array structure as claimed in claim 18, wherein said conducting layers of said plurality of microprobes are connected together to measure one of said biopotential signals.

29. The microprobe array structure as claimed in claim 18, wherein said conducting layers of said plurality of microprobes are mutually isolated, and said microprobe array is used to measure a plurality of said biopotential signals.

30. The microprobe array structure as claimed in claim 29, wherein each of said microprobes with mutually isolated conducting layers is used as a stimulus.

31. The microprobe array structure as claimed in claim 30, wherein when said microprobe is used as a stimulus, a voltage or a current is conducted into said microprobe to electrify said microprobe or render pressure to the punctured location.

32. The microprobe array structure as claimed in claim 18, wherein a shape of each of said plurality of microprobes is a square, a circle, or an irregular shape.

33. The microprobe array structure as claimed in claim 18, wherein the microprobe is hollow.