Endoprosthesis coating

• US 7,942,926 B2
• Filed: 07/11/2007
• Issued: 05/17/2011
• Est. Priority Date: 07/11/2007
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Dorogy, Bill, Benco, John
• Primary Examiner(s): Gherbi; Suzette J
• Application Number:
  US11/776,304
• Publication Number:
  US 20090018647A1
• Time in Patent Office: 1,406 Days
• Field of Search: 623/1.46, 623/11.11, 623/16.11, 523/113, 428/447
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/026 Ceramic or ceramic-like structures, e.g. glasses
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An endoprosthesis, such as a stent, includes a chemical tie layer formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic.

Claims

1. An endoprosthesis, comprising:

a body including a ceramic coating on a surface thereof, the ceramic coating having an Sdr of about 10 or less and an Sq of about 10 or less,

a tie layer covalently bonded to the ceramic coating, and

a polymeric coating adhered to the tie layer.

2. The endoprosthesis of claim 1, wherein the polymeric coating includes a drug.

3. The endoprosthesis of claim 1, wherein the ceramic coating has a globular morphology.

4. The endoprosthesis of claim 1, wherein the ceramic coating has surface oxygen content of about 80% or more.

8. The endoprosthesis of claim 1, wherein the ceramic coating comprises a material selected from among an oxide and IROX.

9. The endoprosthesis of claim 1, wherein the tie layer is selected from silanes, phosphonates, and titanates.

10. The endoprosthesis of claim 1, wherein the polymeric coating is adhered to the tie layer by covalent bonding or by non-covalent adherence.

5. An endoprosthesis, comprising:

a body including a ceramic coating on a surface thereof, the ceramic coating having an Sdr of about 120 to 200 and an Sq of about 20 or more,

a tie layer non-covalently adhered to the ceramic coating, and

a polymeric coating adhered to the tie layer.

6. The endoprosthesis of claim 5, wherein the ceramic coating has a defined grain morphology.

7. The endoprosthesis of claim 5, wherein the ceramic coating has a surface oxygen content of about 80% or less.

21. The endoprosthesis of claim 5, wherein the polymeric coating includes a drug.

22. The endoprosthesis of claim 5, wherein the ceramic coating comprises a material selected from among a oxide and IROX.

23. The endoprosthesis of claim 5, wherein the tie layer is selected from silanes, phosphonates, and titanates.

24. The endoprosthesis of claim 5, wherein the polymeric coating is adhered to the tie layer by covalent bonding or by non-covalent adherence.

11. An endoprosthesis, comprising:

a body including a ceramic coating on a surface thereof,

a tie layer covalently bonded to the ceramic coating, and

a polymeric coating adhered to the tie layer,

wherein the polymeric coating and the ceramic coating have an adhesion increased about 50% or greater by the tie layer.

25. The endoprosthesis of claim 11, wherein the polymeric coating includes a drug.

26. The endoprosthesis of claim 11, wherein the ceramic coating comprises a material selected from among a oxide and IROX.

27. The endoprosthesis of claim 11, wherein the tie layer is selected from silanes, phosphonates, and titanates.

28. The endoprosthesis of claim 11, wherein the polymeric coating is adhered to the tie layer by covalent bonding or by non-covalent adherence.

12. A method of forming an endoprosthesis, comprising:

forming a ceramic and a non-ceramic, non-metal overlayer on the ceramic such that,

the ceramic has an Sdr of about 10 or less, and the overlayer is covalently bonded to the ceramic, or

the ceramic has an Sdr of about 100 or greater, and the overlayer is non-covalently adhered to the ceramic, or

the ceramic has an Sdr between about 10 and 100 and the overlayer is non-covalently adhered or covalently bonded to the ceramic.

13. The method of claim 12, wherein the ceramic having the Sdr of about 10 or less has a globular morphology.

14. The method of claim 12, wherein the ceramic having the Sdr of about 100 or greater has a defined grain morphology.

15. The method of claim 12, wherein the ceramic is an oxide or IROX.

16. The method of claim 12, wherein the covalent bond is through oxygen moieties of the ceramic.

17. The method of claim 12, wherein the overlayer is a silane, phosphate or titanate.

18. The method of claim 12, further comprising forming a polymer layer on the overlayer.

19. The method of claim 18, wherein the polymer layer includes a drug.

20. The method of claim 18, wherein the polymer layer and the ceramic has an adhesion increased about 10% or greater by the overlayer.