Drug delivery device

• US 7,943,162 B2
• Filed: 12/07/2006
• Issued: 05/17/2011
• Est. Priority Date: 10/21/1999
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: Alcon Incorporated
• Inventors: Missel, Paul J., Yaacobi, Yoseph
• Primary Examiner(s): Sheikh; Humera N
• Application Number:
  US11/567,892
• Publication Number:
  US 20070092570A1
• Time in Patent Office: 1,622 Days
• Field of Search: None
• US Class Current: 424/427
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

Drug delivery devices, and methods of delivering pharmaceutically active agents to a target tissue within a body using such devices, are disclosed. One drug delivery device includes a body having an internal surface for disposing on a target tissue and a well having an opening to the internal surface. An inner core comprising a drug containing portion and an expandable material is disposed in the well.

Claims

1. A drug delivery device, comprising:

a body having an internal surface for disposing on a target tissue and a well having an opening to said internal surface; and

an inner core disposed in said well, comprising;

a tablet comprising a pharmaceutically active agent and a second surface disposed proximate said opening, wherein said pharmaceutically active agent is delivered to said target tissue from said tablet through said opening without having to pass through a polymer; and

a hydrogel disposed between said tablet and an inner wall of said well opposite said opening, wherein said hydrogel expands to maintain said second surface proximate said opening as said tablet erodes over time and when said hydrogel is in contact with a fluid from said target tissue.

2. The drug delivery device of claim 1 wherein said body further comprises a channel separate from said well for communicating said fluid from said internal surface to said hydrogel.

3. The drug delivery device of claim 2 wherein said channel has a plug that allows passage of said fluid but not said tissue.