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Fungal dipeptidyl peptidase IV (DPPIV) enzyme for reagent use

  • US 7,943,340 B2
  • Filed: 07/03/2008
  • Issued: 05/17/2011
  • Est. Priority Date: 08/25/2003
  • Status: Active Grant
First Claim
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1. A method for removing an aminoterminal Xaa-Pro tag from a protein, wherein Xaa is any amino acid, comprising the steps of:

  • (1) purification of the protein by covalent capture, and,(2) contacting the protein with a polypeptide comprising an amino acid sequence which is at least 95% identical to SEQ ID NO;

    35, or a fragment thereof, wherein said polypeptide or fragment has dipeptidyl peptidase IV activity, wherein the DPPIV activity consists of cleavage of the aminoterminal Xaa-Pro tag of the protein such that the aminoterminal Xaa-Pro is removed.

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