Pharmaceutical application of 15- or 16-substituted testosterone analogues

• US 7,943,602 B2
• Filed: 09/05/2003
• Issued: 05/17/2011
• Est. Priority Date: 09/05/2002
• Status: Expired due to Fees

• Current Assignee: Pantarhei Bioscience B.V.
• Original Assignee: Pantarhei Bioscience B.V.
• Inventors: Van Der Linden, René Frank, Bunschoten, Evert Johannes, Coelingh Bennink, Herman Jan Tijmen
• Primary Examiner(s): Padmanabhan; Sreeni
• Assistant Examiner(s): Javanmard; Sahar
• Application Number:
  US10/526,730
• Publication Number:
  US 20060122158A1
• Time in Patent Office: 2,811 Days
• Field of Search: 514/170, 514/171, 514/17, 514/8
• US Class Current: 514/171
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 31/568 substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/16 Masculine contraceptives
• CPC Class Codes: A61P 5/26 Androgens

Abstract

The invention relates to pharmaceutical dosage units for oral, transmucosal or transdermal administration containing 15- or 16-substituted testosterone analogues, as well as to therapeutic methods that employ these testosterone analogues. More particularly, the invention is concerned with such pharmaceutical dosage units containing at least 10 μg of an androgenic steroid selected from the group consisting of 15-hydroxytestosterones, 16-hydroxytestosterones, precursors thereof and mixtures of these hydroxytestosterones and/or their precursors; and a pharmaceutically acceptable excipient. The term “15-hydroxytestosterones” encompasses both 15α-hydroxytestosterone (15α, 17β-dihydroxy-4-androsten-3-one) and 15β-hydroxytestosterone (15β, 17β-dihydroxy-4-androsten-3-one). Similarly, the term “16-hydroxytestosterones” encompasses both 16α-hydroxytestosterone hydroxytestosterone (16α, 17β-dihydroxy-4-androsten-3-one) and 16β-hydroxytestosterone (16β, 17β-dihydroxy-4-androsten-3-one). The androgenic steroids according to the invention are advantageously employed in e.g. a method of treating or preventing androgen deficiency or a method of hormonal contraception.

Claims

1. A pharmaceutical oral dosage unit containing at least 10 μ

g of an estrogen and at least 10 μ

g of a steroid selected from the group consisting of 15-hydroxytestosterones, precursors thereof, mixtures thereof and precursors of said mixtures; and

a pharmaceutically acceptable excipient, wherein said oral dosage unit is selected from the group consisting of a tablet, a capsule and a chachet, wherein the precursors of the hydroxytestosterones are derivatives of the hydroxytestosterones wherein a hydrogen atom of at least one hydroxyl group has been substituted by an acyl radical of a hydrocarbon carboxylic, sulfonic or sulfamic acid of 1-25 carbon atoms;

tetrahydrofuranyl;

tetrahydropyranal;

or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue, and wherein the pharmaceutical oral dosage unit is orally active.

2. The pharmaceutical oral dosage unit according to claim 1, wherein the steroid is selected from the group consisting of 15α

-hydroxytestosterone, precursors thereof, mixtures of 15α

-hydroxytestosterone, and precursors of these mixtures of these hydroxytestosterones.

3. The pharmaceutical oral dosage unit according to claim 1, wherein the steroid is selected from the group consisting of 15β

-hydroxytestosterone, precursors thereof, mixtures of 15β

-hydroxytestosterone, and precursors of these mixtures of these hydroxytestosterones.

4. The pharmaceutical oral dosage unit according to claim 1, wherein the oral dosage unit is a tablet.

5. The pharmaceutical oral dosage unit according to claim 1, wherein the oral dosage unit contains between 20 μ

g and 1000 mg of the androgenic steroid.

6. The pharmaceutical oral dosage unit according to claim 1, wherein the oral dosage unit additionally contains at least 10 μ

g of a progestogen.

7. A method of hormone replacement therapy in a female mammal, said method comprising oral administration to said mammal of the oral dosage unit according to claim 1.

8. The method according to claim 7, wherein the method comprises the administration of the steroid in an average daily amount in the range of 0.5 μ

g to 1.5 mg per kg of bodyweight.

9. A method of contraception in a female mammal, said method comprising oral administration to said mammal of the oral dosage unit according to claim 1.

10. The method according to claim 9, wherein the method comprises the administration of the steroid in an average daily amount in the range of 0.5 μ

g to 1.5 mg per kg of bodyweight.