Iontophoretic drug delivery system

• US 7,945,320 B2
• Filed: 08/15/2008
• Issued: 05/17/2011
• Est. Priority Date: 08/17/2007
• Status: Expired due to Fees

• Current Assignee: Isis Biopolymer, Inc.
• Original Assignee: Isis Biopolymer, Inc.
• Inventors: Durand, Emma Amelia
• Primary Examiner(s): Stigell; Theodore J
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US12/192,540
• Publication Number:
  US 20090048556A1
• Time in Patent Office: 1,005 Days
• Field of Search: 604/20, 604/501, 604/890.1
• US Class Current: 604/20
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: H05K 1/095 for polymer thick films, i.e. having a permanent organic polymeric binder
• CPC Class Codes: H05K 1/189 characterised by the use of a flexible or folded printed circuit H05K3/326 takes precedence
• CPC Class Codes: H05K 2201/10037 Printed or non-printed battery
• CPC Class Codes: H05K 3/321 by conductive adhesives

Abstract

The iontophoretic drug delivery system includes electrodes controlled by a microprocessor controller to drive charged molecules contained in a drug reservoir through the skin into the issues of a patient. The iontophoretic drug delivery system further includes an antenna connected to the programmable microprocessor. The antenna allows for the programming of the microprocessor and for the exchange of patient, drug, and treatment related information between the microprocessor and an external device. The iontophoretic drug delivery system is also provided with buttons to allow a patient to manually activate the drug delivery system. The iontophoretic drug delivery system is housed within a thin polyester film membrane.

Claims

1. An iontophoretic drug delivery system for driving charged drug molecules into a tissue, comprising:

a flexible body configured to conform to a portion of a patient'"'"'s body that includes the tissue, the flexible body including a top surface, a bottom surface, and at least one through hole;

a drug reservoir holding the charged drug molecules;

an iontophoretic electrode configured to iontophoretically deliver the charged drug molecules from the drug reservoir into the tissue, the electrode being formed of an electroconductive material printed on the bottom surface of the flexible body, wherein the drug reservoir is located adjacent to the iontophoretic electrode such that the iontophoretic electrode is between the drug reservoir and the flexible body;

a microprocessor controller configured to control iontophoretic delivery of the charged drug molecules from the drug reservoir into the tissue by the iontophoretic electrode, the microprocessor located adjacent to the top surface of the flexible body;

circuitry that couples the microprocessor to the iontophoretic electrode, the circuitry being formed of flexible electroconductive material printed on the top surface of the flexible body;

an electroconductive material in the at least one through hole that couples the circuitry to the iontophoretic electrode, wherein the electroconductive material fills the through hole such that moisture is prevented from passing from the bottom surface to the top surface via the through hole when at least a portion of the bottom surface is located adjacent to the tissue;

an antenna coupled to the microprocessor controller, whereby the microprocessor controller is programmed by signals sent through the antenna; and

a battery coupled to the microprocessor controller located adjacent to the top surface of the flexible body.

2. The system of claim 1, wherein the drug reservoir comprises a gel pad.

3. The system of claim 1, wherein the drug reservoir comprises a membrane.

4. The system of claim 2, wherein the charged drug molecules are carried within the gel pad.

5. The system of claim 3, wherein the charged drug molecules are carried within the membrane.

6. The system of claim 1, wherein the circuitry includes flexible printed wires.

7. The drug delivery system of claim 6, wherein the flexible printed wires are made of silver or silver chloride.

8. The drug delivery system of claim 1, wherein the electroconductive material in the at least one through hole includes conductive cement.

23. The drug delivery system of claim 1, wherein the antenna is formed of flexible electroconductive material printed on the flexible body.

24. The drug delivery system of claim 1, wherein the flexible body includes a single flexible layer.

9. An iontophoretic drug delivery system for driving charged drug molecules into a tissue, comprising:

a flexible body configured to conform to a portion of a patient'"'"'s body that includes the tissue, the flexible body including a top surface, a bottom surface, and at least one through hole;

a drug reservoir that holds the charged drug molecules;

an iontophoretic electrode configured to iontophoretically deliver the charged drug molecules from the drug reservoir into the tissue, the electrode being formed of an electroconductive material printed on the bottom surface of the flexible body, wherein the drug reservoir is located adjacent to the iontophoretic electrode such that the iontophoretic electrode is between the drug reservoir and the flexible body;

a microprocessor controller configured to control iontophoretic delivery of the charged drug molecules from the drug reservoir into the tissue by the iontophoretic electrode, the microprocessor located adjacent to the top surface of the flexible body;

circuitry that couples the microprocessor to the iontophoretic electrode, the circuitry being formed of flexible electroconductive material printed on the top surface of the flexible body;

an electroconductive material in the at least one through hole that couples the circuitry to the iontophoretic electrode, wherein the electroconductive material fills the through hole such that moisture is prevented from passing from the bottom surface to the top surface via the through hole when at least a portion of the bottom surface is located adjacent to the tissue; and

a high-tack adhesive placed around an outer edge of the bottom surface of the flexible body and a low-tack adhesive placed in a center of the bottom surface of the flexible body.

10. The system of claim 9, further comprising an antenna coupled to the microprocessor controller, whereby the microprocessor controller is programmed by signals sent through the antenna.

11. The system of claim 9, further comprising a battery coupled to the microprocessor controller.

12. The system of claim 9, wherein the drug reservoir comprises a gel pad.

13. The system of claim 9, wherein the drug reservoir comprises a membrane.

14. The system of claim 12, wherein the charged drug molecules are carried within the gel pad.

15. The system of claim 13, wherein the charged drug molecules are carried within the membrane.

16. The system of claim 9, wherein the circuitry includes flexible printed wires.

17. The drug delivery system of claim 16, wherein the flexible printed wires are made of silver or silver chloride.

18. The drug delivery system of claim 9, wherein the electroconductive material in the at least one through hole includes conductive cement.

19. The drug delivery system of claim 9, further comprising a moisture sensor that detects a level of moisture at an interface between the system and the patient'"'"'s skin.

20. An iontophoretic drug delivery system for driving charged drug molecules into a tissue, comprising:

a flexible body configured to conform to a portion of a patient'"'"'s body that includes the tissue, the flexible body including a top surface, a bottom surface, and at least one through hole;

a drug reservoir that holds the charged drug molecule;

a tissue permeation enhancer that enhances permeation of the drug molecule into the tissue;

an iontophoretic electrode configured to iontophoretically deliver the charged drug molecule from the drug reservoir into the tissue, the electrode being formed of an electroconductive material printed on the bottom surface of the flexible body, wherein the drug reservoir is located adjacent to the iontophoretic electrode such that the iontophoretic electrode is between the drug reservoir and the flexible body;

a microprocessor controller configured to control iontophoretic delivery of the charged drug molecules from the drug reservoir into the tissue by the iontophoretic electrode, the microprocessor located adjacent to the top surface of the flexible body;

circuitry that couples the microprocessor to the electrode, the circuitry being formed of flexible electroconductive material printed on the top surface of the flexible body;

an electroconductive material in the at least one through hole that couples the circuitry to the iontophoretic electrode, wherein the electroconductive material fills the through hole such that moisture is prevented from passing from the bottom surface to the top surface via the through hole when at least a portion of the bottom surface is located adjacent to the tissue; and

a battery coupled to the microprocessor controller located adjacent to the top surface of the flexible body.

21. A drug delivery system according to claim 20, wherein the permeation enhancer is in the drug reservoir.

22. A drug delivery system according to claim 21, wherein the permeation enhancer is an excipient.

25. An iontophoretic drug delivery system for driving charged drug molecules into a tissue, comprising:

a flexible body configured to conform to a portion of a patient'"'"'s body that includes the tissue, the flexible body including a top surface, a bottom surface, and at least one through hole;

a drug reservoir holding the charged drug molecules;

an iontophoretic electrode configured to iontophoretically deliver the charged drug molecules from the drug reservoir into the tissue, the electrode being formed of an electroconductive material printed on the bottom surface of the flexible body, wherein the drug reservoir is located adjacent to the iontophoretic electrode such that the iontophoretic electrode is between the drug reservoir and the flexible body;

a battery located adjacent to the top surface of the flexible body;

circuitry that couples the iontophoretic electrode to the battery, the circuitry being formed of flexible electroconductive material printed on the top surface of the flexible body; and

an electroconductive material in the at least one through hole that couples the circuitry to the iontophoretic electrode, wherein the electroconductive material fills the through hole such that moisture is prevented from passing from the bottom surface to the top surface via the through hole when at least a portion of the bottom surface is located adjacent to the tissue.

26. The drug delivery system of claim 25, wherein the iontophoretic electrode is electrically coupled to the electroconductive material via a length of wiring printed on the bottom surface of the flexible body.