Compact apparatus and methods for non-invasively measuring hemodynamic parameters

• US 7,946,994 B2
• Filed: 10/07/2004
• Issued: 05/24/2011
• Est. Priority Date: 10/07/2004
• Status: Active Grant

• Current Assignee: Zhejiang Shanshi Biological Medical Devices Company Limited
• Original Assignee: Tensys Medical Inc. (Recorders & Medicare Systems Pvt Ltd.)
• Inventors: Hempstead, Russell D., Finburgh, Simon E., Perona, Mark W.
• Primary Examiner(s): MARMOR II, CHARLES ALAN
• Application Number:
  US10/961,460
• Publication Number:
  US 20060079792A1
• Time in Patent Office: 2,420 Days
• Field of Search: 600481-485, 600500-504
• US Class Current: 600/485
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/681 Wristwatch-type devices

Abstract

Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises spatially compact “bracelet” embodiment adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an optional alignment apparatus which moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. The alignment apparatus also advantageously allows the sensor position to be maintained when the fixture is removed from the subject, such as during patient transport. A completely autonomous variant of the bracelet apparatus having internal power supply and wireless interfaces is also disclosed. Methods for positioning the alignment apparatus and sensor and providing treatment to the subject are also described.

Claims

1. Physiologic sensing apparatus, comprising:

at least one pressure sensor;

a substantially arcuate-shaped support structure adapted to receive at least a portion of the anatomy of a subject therein, said support structure comprising;

a first portion;

a second portion; and

a third portion coupled to said first and second portions and comprising an actuator mechanism, said first, second and third portions cooperating to surround a substantial fraction of the circumference of said anatomy; and

a preload mechanism adapted to trigger locking of said substantially arcuate-shaped support structure when a predetermined level of compressive force is applied to said support structure;

wherein said support structure is adapted to couple at least one force felt by said at least one sensor to said at least portion of said anatomy; and

wherein upon actuation of said actuator mechanism, said first, second and third portions are kept in substantially constant relationship to one another.

2. The apparatus of claim 1, wherein said actuator is configured to controllably move said at least one pressure sensor.

3. The apparatus of claim 2, wherein said controllable movement of said at least one pressure sensor comprises applanating said at least one pressure sensor against the tissue of a limb of said subject proximate a blood vessel thereof.

4. The apparatus of claim 2, wherein said controllable movement of said at least one pressure sensor comprises movement in at least one of a lateral and/or proximal direction relative to a blood vessel of a limb of said anatomy.

5. The apparatus of claim 1, wherein said at least one pressure sensor is configured to generate first signals relating to pressure applied thereto.

6. The apparatus of claim 5, further comprising a signal interface adapted to transmit second signals to an external device, said second signals comprising scaled blood pressure signals generated based at least in part on said first signals.

7. The apparatus of claim 6, wherein said scaled blood pressure signals are scaled at least in part using at least one physiologic parameter associated with said subject.

8. An apparatus for performing physiologic sensing on a living subject, said apparatus comprising:

at least one pressure sensor, said pressure sensor being configured to generate first signals relating to pressure applied thereto;

a substantially U-shaped body adapted to receive at least a portion of the anatomy of said living subject therein; and

an actuator apparatus coupled to said at least one pressure sensor and said body, said actuator being adapted to controllably move said at least one pressure sensor;

wherein said apparatus is configured to lock said body and prevent rotation of one or more components thereof when a predetermined level of compressive force is applied thereto.

9. The apparatus of claim 8, wherein said body comprises first, second and third articulated portions, said first, second and third articulated portions cooperating to surround a substantial fraction of the circumference of said anatomy.

10. The apparatus of claim 9, wherein said articulation is such that, actuation of said actuator mechanism, said first, second and third articulated portions are kept in substantially constant relationship to one another.

11. The apparatus of claim 8, wherein said actuator apparatus is substantially integral with said body and adapted to move said at least one pressure sensor.

12. Physiologic sensing apparatus, comprising:

at least one sensor; and

a substantially U-shaped support structure adapted to receive at least a portion of a wrist region of a subject therein, said support structure comprising;

a first portion;

a second portion; and

a third portion coupled to said first and second portions, said first, second and third portions cooperating to surround a substantial fraction of the circumference of said wrist region when said wrist region is received therein; and

a preload mechanism adapted to trigger said first and second portions to lock into position with respect to one another when a predetermined level of compressive force is applied to said second and third portions contemporaneously;

wherein said support structure further comprises an actuator, said actuator being disposed on said support structure so as to couple to said at least one sensor, said actuator configured to exert a force pressing said at least one sensor against said wrist region;

and

wherein upon actuation of said actuator, said first, second and third portions are kept in substantially constant relationship to one another.

13. The apparatus of claim 12, wherein said support structure comprises a bracelet apparatus adapted to fit substantially over said wrist and be adjusted to substantially conform therewith.

14. The apparatus of claim 12, wherein said actuator is also coupled to said support structure so as to transmit at least one other force from said at least one sensor to said support structure.

15. The apparatus of claim 14, wherein said at least one other force from said at least one sensor to said support structure comprises a reaction force necessary to substantially achieve equilibrium with said force generated by said actuator pressing said at least one sensor against said wrist.

16. The apparatus of claim 12, wherein said coupling of said at least one force to said wrist region comprises transferring said force to the back side of the wrist region.

17. The apparatus of claim 12, further comprising a brace, wherein said coupling to said wrist region occurs at least partly via said brace.

18. The apparatus of claim 12, wherein said second portion is articulated to rotate with respect to said third portion, and said actuation of said actuator substantially frustrates said rotation.

19. The apparatus of claim 18, wherein said second portion is articulated to rotate with respect to said third portion around two different axes, and said actuation of said actuator substantially frustrates said rotation in both axes.