Kit for the conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
First Claim
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1. A kit for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:
- a diffusion cell configured to be connected to a source of nitrogen dioxide;
a permeation tube connected to the diffusion cell; and
a receptacle configured to attach to the permeation tube, the receptacle including an inlet, an outlet, and a surface-active material coated with an antioxidant, wherein the inlet is configured to receive the flow of nitrogen dioxide from the permeation tube and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature.
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Abstract
A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
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Citations
40 Claims
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1. A kit for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:
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a diffusion cell configured to be connected to a source of nitrogen dioxide; a permeation tube connected to the diffusion cell; and a receptacle configured to attach to the permeation tube, the receptacle including an inlet, an outlet, and a surface-active material coated with an antioxidant, wherein the inlet is configured to receive the flow of nitrogen dioxide from the permeation tube and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A kit for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:
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a pressure regulator configured to be connected to a source of nitrogen dioxide; a receptacle configured to attach to the pressure regulator, the receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive the flow from a source of gaseous nitrogen dioxide and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature, wherein the receptacle is configured to attach to the gas bottle having nitrogen dioxide in air and capable of providing a flow of gaseous nitrogen dioxide and air. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method of providing a therapeutic amount of nitric oxide to a mammal comprising:
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diffusing nitrogen dioxide into a gas flow; exposing the nitrogen dioxide to a surface-active material coated with an antioxidant to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature; and transporting the nitric oxide in a therapeutic amount to a mammal. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification