TGF-β3 mutants
First Claim
1. An isolated TGF-β
- 3 protein comprising a substitution or substitutions at the amino acid residues selected from the group consisting of (a) the glutamic acid residue at position 12, (b) the arginine residue at position 52, and (c) both the glutamic acid residue at position 12 and the arginine residue at position 52, wherein each of the substituted positions corresponds to the position in full-length wild type TGF-β
3 as set forth in SEQ ID NO;
1.
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Accused Products
Abstract
The invention provides TGF-β3s, or fragments or derivatives thereof, wherein the alpha-helix-forming domain between amino acid residues (58) and (67) of full-length wild type TGF-β3 comprises at least one alpha-helix-stabilizing substitution. The invention also provides TGF-β3s, or fragments or derivatives thereof, wherein the Glycine residue at position (63) of full-length wild type TGF-β3 is replaced with Proline. Further still, the invention provides TGF-β3s, or fragments or derivatives thereof, comprising a substitution of the Glutamic acid residue at position (12) of full-length wild type TGF-β3 and/or the Arginine residue at position (52) of full-length wild type TGF-β3. The invention also provides medicaments and methods of treatment using such TGF-β3s.
15 Citations
8 Claims
-
1. An isolated TGF-β
- 3 protein comprising a substitution or substitutions at the amino acid residues selected from the group consisting of (a) the glutamic acid residue at position 12, (b) the arginine residue at position 52, and (c) both the glutamic acid residue at position 12 and the arginine residue at position 52, wherein each of the substituted positions corresponds to the position in full-length wild type TGF-β
3 as set forth in SEQ ID NO;
1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 3 protein comprising a substitution or substitutions at the amino acid residues selected from the group consisting of (a) the glutamic acid residue at position 12, (b) the arginine residue at position 52, and (c) both the glutamic acid residue at position 12 and the arginine residue at position 52, wherein each of the substituted positions corresponds to the position in full-length wild type TGF-β
Specification