Method of treating stroke or brain injury patients based on the intravenous administration of magnesium cations and concurrent administration of an oxygen gas mixture

• US 7,947,310 B2
• Filed: 04/04/2006
• Issued: 05/24/2011
• Est. Priority Date: 04/05/2005
• Status: Expired due to Fees

• Current Assignee: Relox Medical LLC (Striper Energy, Inc.)
• Original Assignee: Relox Medical LLC (Striper Energy, Inc.)
• Inventors: Rind, Bruce
• Primary Examiner(s): ALSTRUM ACEVEDO, JAMES HENRY
• Application Number:
  US11/397,428
• Publication Number:
  US 20060280807A1
• Time in Patent Office: 1,876 Days
• Field of Search: 424/600, 424/613, 424/681, 514/771
• US Class Current: 424/681
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours

Abstract

A method for treating a patient comprising: (a) injecting into the bloodstream of a patient is breathing a gas mixture having greater than 25% oxygen an aqueous solution comprising: 0.1 to 0.8 M Mg++ and having an osmolarlity less than about 1500 mOSm/l; and (b) increasing the rate of injection at least until the patient feels a sensation of warmth is described.

Claims

1. A method for treating a human patient comprising:

(a) injecting into the bloodstream of a patient who is breathing a gas mixture having greater than 25% oxygen an aqueous solution comprising;

0.1 to 0.8 M Mg⁺⁺ and having an osmolarity less than 1500 mOSm/l; and

(b) increasing the rate of injection at least until the patient feels a sensation of warmth in a target area of the patient'"'"'s body, wherein the patient has suffered a stroke or brain injury.

2. The method of claim 1 wherein the patient is administered a breathing mixture comprising at least 40% oxygen.

3. The method of claim 2 wherein the patient is administered a breathing mixture comprising at least 60% oxygen.

4. The method of claim 2 wherein the patient is administered a breathing mixture comprising at least 90% oxygen.

5. The method of claim 1 wherein the breathing mixture includes at least 0.5% CO2.

6. The method of claim 1 wherein the breathing mixture includes 0.5% to 6% CO2.

7. The method of claim 2 wherein the breathing mixture is administered to the patient at greater than normal atmospheric pressure.

8. The method of claim 1 wherein the rate of injection is not substantially increased after the patient feels a sensation of warmth.

9. The method of claim 1 wherein the total amount of solution administered is between 0.5 ml/kg and 2 ml/kg of patient body weight.

10. The method of claim 1 wherein the average rate of injection is greater than 0.1 ml/sec.

11. The method of claim 1 wherein the osmolarity of the solution is less than 1200 mOsm/L.

12. The method of claim 1 wherein the osmolarity of the solution is less than 1100 mOsm/L.

13. The method of claim 1 wherein the osmolarity of the solution is less than 1000 mOsm/L.

14. The method of claim 1 wherein the osmolarity of the solution is less than 900 mOsm/L.

15. The method of claim 1 wherein the osmolarity of the solution is between 200 and 1100 mOsm/L.

16. The method of claim 1 wherein the solution contains up to 6 mg/ml ascorbic acid.

17. The method of claim 1 wherein the solution contains 0.1 to 0.7 M magnesium chloride.

18. The method of claim 1 wherein the solution contains 0.1 to 0.7 M magnesium sulfate.

19. The method of claim 1 wherein the solution contains one or more of vitamin B12, vitamin B6 and vitamin B5

20. The method of claim 1 wherein the solution contains vitamin B12, vitamin B6 and vitamin B5.

21. The method of claim 1 wherein the solution contains less than 1% by weight calcium gluconate.

22. The method claim 1 wherein the solution does not contain calcium gluconate.

23. The method of claim 1 wherein the solution contain less than 0.001 M Ca²⁺.

24. The method of claim 1 wherein the patient is reclining during treatment.

25. The method of claim 1 wherein the patient has consumed at least 200 calories within 3 hours prior to treatment.

26. The method of claim 1 wherein the patient consumed or has been administered at least 2 ml/kg body weight of water within 3 hours prior to treatment.

27. A method of treating a human patient, comprising the steps of:

a) providing an injectable solution comprising one or more components, including magnesium ions;

b) administering the solution by injecting the solution into the patient'"'"'s bloodstream, while adjusting the injection rate based upon temperature feedback from the patient;

c) providing breathable oxygen comprising at least 25% oxygen, to the patient in the course of administering the solution;

whereby the solution is administered to the patient at an increasing rate until the patient temperature feedback indicates an increase in warmth in the injured region of the patient, whereupon the injection rate is adjusted in order to maintain the increase in warmth for a desired period of time, wherein the patient has suffered a stroke or brain injury.

28. A method according to claim 27 wherein oxygen is delivered before, during or after administration of the solution.

29. A method according to claim 27 wherein the increase in warmth is maintained for on the order of seconds to minutes.

30. The method of claim 27 wherein the solution contains one or more B vitamins.