Kits for diagnosing a hypophosphatemic disorder

• US 7,947,810 B2
• Filed: 11/07/2007
• Issued: 05/24/2011
• Est. Priority Date: 07/19/2000
• Status: Expired due to Fees

• Current Assignee: ADVANCED RESEARCH & TECHNOLOGY INSTITUTE, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche Genetik
• Original Assignee: ADVANCED RESEARCH & TECHNOLOGY INSTITUTE, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche Genetik
• Inventors: Meitinger, Thomas, Strom, Tim Matthias, White, Ken, Econs, Michael
• Primary Examiner(s): Saoud; Christine J
• Application Number:
  US11/983,190
• Publication Number:
  US 20090311792A1
• Time in Patent Office: 1,294 Days
• Field of Search: None
• US Class Current: 530/387.9
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A01K 2217/075 inducing loss of function, i.e. knock out
• CPC Class Codes: A61K 38/1825 Fibroblast growth factor [FGF]
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 3/12 for electrolyte homeostasis
• CPC Class Codes: C07K 14/50 Fibroblast growth factor [FGF]
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers
• CPC Class Codes: C12Q 2600/158 Expression markers
• CPC Class Codes: C12Q 2600/172 Haplotypes

Abstract

The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.

Claims

1. A kit for diagnosing a hypophosphatemic disorder in a mammal, said kit comprising an antibody that detects a polypeptide comprising the amino acid sequence of SEQ ID NO:

2, wherein an elevated level of said detected polypeptide is an indication that said mammal is afflicted with said hypophosphatemic disorder, wherein said hypophosphatemic disorder is selected from the group consisting of X-linked hypophosphatemic rickets and tumor induced osteomalacias.