Time domain monitoring of myocardial electrical stability

• US 7,949,390 B1
• Filed: 02/14/2006
• Issued: 05/24/2011
• Est. Priority Date: 02/14/2006
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Wirasinghe, Rushani, Farazi, Taraneh Ghaffari
• Primary Examiner(s): Bockelman; Mark W
• Assistant Examiner(s): Dinga; Roland
• Application Number:
  US11/354,629
• Time in Patent Office: 1,925 Days
• Field of Search: 600/515, 600/509, 600/510, 600/513, 600/516, 600/517, 600/519, 607372-375, 607/9
• US Class Current: 600/515
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial electrical stability. A patient'"'"'s heart is paced for a period of time using a patterned pacing sequence that repeats every N beats, and an electrical signal is obtained that is representative of a plurality of consecutive beats of the patient'"'"'s heart while it is being paced using the patterned pacing sequence that repeats every N beats. Myocardial electrical stability is then analyzed using time domain techniques that are tailored to the patterned pacing sequence used to pace the patient'"'"'s heart. In other embodiments, the patient'"'"'s heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

Claims

1. In an implantable system, a method for time domain monitoring of myocardial electrical stability, comprising:

(a) pacing a patient'"'"'s heart for a period of time using a patterned pacing sequence that repeats every N beats, where N is an integer that is at least 3;

(b) obtaining an electrical signal that is representative of a plurality of consecutive beats of the patient'"'"'s heart while the patient'"'"'s heart is being paced using the patterned pacing sequence that repeats every N beats;

(c) dividing the plurality of consecutive beats into a plurality of sets of N consecutive beats;

(d) for each set of N consecutive beats, of the plurality of sets of N consecutive beats, determining one or more pairwise combination of consecutive pairs of beats within the set of N consecutive beats;

(e) cumulative averaging or cumulative summing corresponding pairwise combinations determined for the plurality of sets of N consecutive beats to thereby produce a plurality of cumulative values; and

(f) monitoring myocardial electrical stability based on the cumulative values;

wherein steps (b), (c), (d), (e) and (f) are all performed in the time domain without any transformation into the frequency domain.

2. The method of claim 1, wherein step (f) comprises determining, based on the cumulative values, whether electrical alternans are present.

3. The method of claim 2, wherein:

step (e) comprises cumulative averaging corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

step (f) comprises determining that electrical alternans are present when the cumulative values exceed a specified threshold.

4. The method of claim 2, wherein:

step (e) comprises cumulative summing corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

step (f) comprises determining that electrical alternans are present when a slope of the cumulative values exceeds a specified slope threshold.

5. The method of claim 1, wherein step (f) comprises tracking changes in myocardial electrical stability as steps (a) through (e) are repeated over time.

6. The method of claim 1, further comprising bounding the pairwise combinations determined at step (d) prior to the cumulative averaging or cumulative summing performed at step (e).

7. The method of claim 1, further comprising:

detecting disruptive beats, if they exist, based on the cumulative values determined at step (e); and

if one or more disruptive beats are detected, compensating for the disruptive beats, and performing steps (c), (d) and (e) again before monitoring myocardial electrical stability at step (f).

8. The method of claim 7, wherein:

step (e) comprises cumulative averaging corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

the detecting disruptive beats step comprises detecting a disruptive beat if the cumulative values continually stay within a range and then suddenly go outside the range and continually stay within a further range.

9. The method of claim 7, wherein:

step (e) comprises cumulative summing corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

the detecting disruptive beats step comprises detecting a disruptive beat if the cumulative values continually increase and then suddenly continually decrease.

10. The method of claim 1, wherein step (f) comprises:

measuring one of the following T-wave metrics for each beat;

T-wave amplitude;

T-wave width;

T-wave slope;

T-wave area;

T-wave morphology;

QT interval; and

evoked QT interval; and

determining one or more pairwise differences between measured T-wave metrics of consecutive pairs of beats for each of the plurality of sets of N consecutive beats.

11. An implantable system for time domain monitoring of myocardial electrical stability, comprising:

one or more pulse generator configured to pace a patient'"'"'s heart for a period of time using a patterned pacing sequence that repeats every N beats, where N is an integer that is at least 3;

one or more sensing circuit configured to obtain an electrical signal that is representative of a plurality of consecutive beats of the patient'"'"'s heart while the patient'"'"'s heart is being paced using the patterned pacing sequence that repeats every N beats;

a controller configured to, in the time domain without any transformation into the frequency domain,

divide the plurality of consecutive beats into a plurality of sets of N consecutive beats;

for each set of N consecutive beats, of the plurality of sets of N consecutive beats, determine one or more pairwise combinations of consecutive pairs of beats within the set of N consecutive beats;

cumulative average or cumulative sum corresponding pairwise combinations determined for the plurality of sets of N consecutive beats to thereby produce a plurality of cumulative values; and

monitor myocardial electrical stability based on the cumulative values.

12. The system of claim 11, wherein the controller determines, based on the cumulative values, whether electrical alternans are present.

13. The system of claim 12, wherein the controller:

cumulative averages corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

determines that electrical alternans are present when the cumulative values exceed a specified threshold.

14. The system of claim 12, wherein the controller:

cumulative sums corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

determines that electrical alternans are present when a slope of the cumulative values exceed a specified slope threshold.

15. The system of claim 11, wherein the controller tracks changes in myocardial electrical stability over time.

16. The system claim 11, wherein the controller bounds the pairwise differences prior to the cumulative averaging or cumulative summing.

17. The system of claim 11, wherein the controller:

detects disruptive beats, if they exist, based on the cumulative values; and

if one or more disruptive beats are detected, compensates for the disruptive beats, before monitoring myocardial electrical stability.

18. The system of claim 17, wherein the controller:

cumulative averages corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

detects a disruptive beat if the cumulative values continually stay within a range and then suddenly go outside the range and continually stay within a further range.

19. The system of claim 17, wherein the controller:

cumulative sums corresponding pairwise differences determined for the plurality of sets of N consecutive beats to thereby produce the plurality of cumulative values; and

detects a disruptive beat if the cumulative values continually increase and then suddenly continually decrease.

20. The system of claim 11, wherein the controller:

measures one of the following T-wave metrics for each beat;

T-wave amplitude;

T-wave width;

T-wave slope;

T-wave area;

T-wave morphology;

QT interval; and

evoked QT interval; and

determines one or more pairwise differences between measured T-wave metrics of consecutive pairs of beats for each of the plurality of sets of N consecutive beats.