Acquiring nerve activity from carotid body and/or sinus

• US 7,949,399 B2
• Filed: 10/29/2010
• Issued: 05/24/2011
• Est. Priority Date: 12/27/2007
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Wenzel, Brian Jeffrey, Farazi, Taraneh Ghaffari
• Primary Examiner(s): Patel; Niketa I
• Assistant Examiner(s): EL-KAISSI, HIBA CARINE
• Application Number:
  US12/915,991
• Publication Number:
  US 20110046508A1
• Time in Patent Office: 207 Days
• Field of Search: 607/9, 607/42, 607/44, 607/45, 607/46
• US Class Current: 607/42
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/4047 afferent nerves, i.e. nerves that relay impulses to the central nervous system
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

Claims

1. A method comprising:

identifying one or more regions of neurons of the right carotid sinus nerve or the left carotid sinus nerve as being associated with at least one member of the group consisting of ventilation rate, blood carbon dioxide concentration, blood oxygen concentration and blood pH;

selecting a first electrode configuration from an electrode array to sense a first type of nerve activity of the right carotid sinus nerve or the left carotid sinus nerve and selecting a second electrode configuration to sense a second type of nerve activity of the right carotid sinus nerve or the left carotid sinus nerve, wherein the first type of nerve activity is different from the second type of nerve activity;

acquiring an electroneurogram of the one or more regions;

storing the electroneurogram in an implantable device, wherein the implantable device comprises a memory, and wherein the electroneurogram is stored in the memory of the implantable device;

communicating the stored electroneurogram to another device; and

analyzing the electroneurogram to determine least one member of the group consisting of ventilation rate, blood carbon dioxide concentration, blood oxygen concentration and blood pH.

2. The method of claim 1 further comprising calling for one or more therapeutic actions based at least in part on the analyzing.

3. The method of claim 1 further comprising instructing the implantable device to call for one or more therapeutic actions based at least in part on the analyzing.

4. The method of claim 1 wherein the analyzing comprises comparing at least one of the chemosensory information and the barosenory information to historic information.

5. The method of claim 1 wherein the analyzing comprises use of at least one established relationship between carotid sinus nerve activity and blood pressure.

6. The method of claim 1 wherein the analyzing comprises use of at least one established relationship between carotid sinus nerve activity and blood chemistry.

7. The method of claim 1 further comprising making a diagnosis based at least in part on the analyzing.

8. The method of claim 7 wherein the diagnosis comprises a member selected from a group consisting of sleep apnea, an increase in metabolic demand, hypoglycemia and hypertension.

9. The method of claim 1, wherein the first electrode configuration senses nerve activity at a first location along the right carotid sinus nerve or the left carotid sinus nerve and the second electrode configuration senses nerve activity at a second location along the right carotid sinus nerve or the left carotid sinus nerve, wherein the first and second locations are different.

10. A method comprising:

identifying one or more regions of neurons of the right carotid sinus nerve or the left carotid sinus nerve as being associated with at least one member of the group consisting of ventilation rate, blood carbon dioxide concentration, blood oxygen concentration and blood pH;

selecting a first electrode configuration from an electrode array to sense a first type of nerve activity of the right carotid sinus nerve or the left carotid sinus nerve and selecting a second electrode configuration to sense a second type of nerve activity of the right carotid sinus nerve or the left carotid sinus nerve, wherein the first type of nerve activity is different from the second type of nerve activity;

acquiring an electroneurogram of the one or more regions;

storing the electroneurogram in an implantable device, wherein the implantable device comprises a memory, and wherein the electroneurogram is stored in the memory of the implantable device;

communicating the stored electroneurogram to another device; and

analyzing the electroneurogram to determine least one member of the group consisting of ventilation rate, blood carbon dioxide concentration, blood oxygen concentration and blood pH, wherein the analyzing comprises;

determining a characteristic frequency and fascicle of the electroneurogram, and associating a type of receptor from which the electroneurogram originated from based on the characteristic frequency and fascicle of the electroneurogram.

11. The method of claim 10 further comprising making a diagnosis based on determining at least one member of the group consisting of ventilation rate, blood carbon dioxide concentration, blood oxygen concentration, blood potassium concentration, blood glucose concentration, blood pressure, and blood pH.

12. The method of claim 11 wherein the diagnosis comprises a member selected from a group consisting of sleep apnea, an increase in metabolic demand, hypoglycemia and hypertension.