Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods
First Claim
1. A method for treating neuronal tissue of a patient using electrical stimulation, comprising:
- identifying a location of an infarct region having dysfunctional neuronal tissue that was subjected to a reduced oxygen supply;
based at least in part on the location of the infarct region, identifying an affected region having low morbidity tissue, the affected region including neuronal tissue that, at least during a pre-infarct period, was in neural communication with the dysfunctional neuronal tissue in the infarct region, wherein neuronal tissue in the affected region has reduced neural signal transmission as a result of tissue loss at the infarct region;
implanting at least one electrode at least on, near or adjacent the affected region;
selecting a first set of stimulation parameters such that the neuronal tissue in the affected region is stimulated during a post-acute, pre-chronic period relative to the onset of damage to the low-morbidity neuronal tissue in the affected region; and
selecting a second set of stimulation parameters such that the neuronal tissue in the affected region is stimulated during a chronic period once the onset of damage to the low-morbidity neuronal tissue has occurred; and
controlling a pulse generator to generate electrical pulses and to apply electrical pulses to the patient through the electrode according to the first and second set of stimulation parameters.
2 Assignments
0 Petitions
Accused Products
Abstract
Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
-
Citations
13 Claims
-
1. A method for treating neuronal tissue of a patient using electrical stimulation, comprising:
-
identifying a location of an infarct region having dysfunctional neuronal tissue that was subjected to a reduced oxygen supply; based at least in part on the location of the infarct region, identifying an affected region having low morbidity tissue, the affected region including neuronal tissue that, at least during a pre-infarct period, was in neural communication with the dysfunctional neuronal tissue in the infarct region, wherein neuronal tissue in the affected region has reduced neural signal transmission as a result of tissue loss at the infarct region; implanting at least one electrode at least on, near or adjacent the affected region; selecting a first set of stimulation parameters such that the neuronal tissue in the affected region is stimulated during a post-acute, pre-chronic period relative to the onset of damage to the low-morbidity neuronal tissue in the affected region; and selecting a second set of stimulation parameters such that the neuronal tissue in the affected region is stimulated during a chronic period once the onset of damage to the low-morbidity neuronal tissue has occurred; and controlling a pulse generator to generate electrical pulses and to apply electrical pulses to the patient through the electrode according to the first and second set of stimulation parameters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
-
13. A method for treating neuronal tissue of a patient using electrical stimulation, comprising:
-
identifying a location of an infarct region having dysfunctional neuronal tissue that was subjected to a reduced oxygen supply; based at least in part on the location of the infarct region, identifying an affected region having low morbidity tissue, the affected region including neuronal tissue that, at least during a pre-infarct period, was in neural communication with the dysfunctional neuronal tissue in the infarct region, wherein neuronal tissue in the affected region has reduced neural signal transmission as a result of tissue loss at the infarct region; positioning at least one electrode at least on, near or adjacent the affected region; controlling a pulse generator to generate electrical pulses and to apply electrical pulses to the patient through the electrode according to a set of stimulation parameters comprising a first set of stimulation parameters such that the neuronal tissue in the affected region is stimulated during a post-acute, pre-chronic period relative to the onset of damage to the low-morbidity neuronal tissue in the affected region;
a second set of stimulation parameters such that the neuronal tissue in the affected region is stimulated during a chronic period once the onset of damage to the low-morbidity neuronal tissue has occurred or a combination of the first and second set of stimulation parameters;identifying the onset of a chronic period relative to the occurrence of damage to the neuronal tissue; and directing the patient to engage in adjunctive therapy during the chronic period.
-
Specification