Sinus delivery of sustained release therapeutics
First Claim
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1. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
- a) loading a delivery device with one or more drug-releasing implants;
b) creating access to the paranasal sinus cavity with the loaded delivery device such that at least a portion of the delivery device is advanced into the paranasal sinus cavity; and
c) delivering the one or more drug-releasing implants from the delivery device-into the paranasal sinus cavity,wherein the one or more drug-releasing implants comprise a therapeutic amount of an active agent for the treatment of sinusitis.
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Abstract
The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
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Citations
32 Claims
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1. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
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a) loading a delivery device with one or more drug-releasing implants; b) creating access to the paranasal sinus cavity with the loaded delivery device such that at least a portion of the delivery device is advanced into the paranasal sinus cavity; and c) delivering the one or more drug-releasing implants from the delivery device-into the paranasal sinus cavity, wherein the one or more drug-releasing implants comprise a therapeutic amount of an active agent for the treatment of sinusitis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
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a) loading a delivery device with one or more drug-releasing implants; b) creating access to the paranasal sinus cavity with the loaded delivery device such that at least a portion of the delivery device is advanced into the paranasal sinus cavity; and c) delivering the one or more drug-releasing implants from the delivery device-into the paranasal sinus cavity, wherein the one or more drug-releasing implants comprise a therapeutic amount of an active agent for the reduction of inflammation. - View Dependent Claims (32)
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Specification