Sinus delivery of sustained release therapeutics
First Claim
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1. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
- a) creating access to the paranasal sinus cavity with a delivery device loaded with the drug-releasing implant; and
b) delivering the drug-releasing implant into the paranasal sinus cavity,wherein the drug-releasing implant comprises a therapeutic amount of an active agent for the treatment of sinusitis and wherein the drug-releasing implant has a first delivery configuration and a second configuration, different from the first, having a viscosity that substantially prevents clearance of the implant from the paranasal sinus cavity.
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Abstract
The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
185 Citations
31 Claims
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1. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
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a) creating access to the paranasal sinus cavity with a delivery device loaded with the drug-releasing implant; and b) delivering the drug-releasing implant into the paranasal sinus cavity, wherein the drug-releasing implant comprises a therapeutic amount of an active agent for the treatment of sinusitis and wherein the drug-releasing implant has a first delivery configuration and a second configuration, different from the first, having a viscosity that substantially prevents clearance of the implant from the paranasal sinus cavity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
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a) creating access to the paranasal sinus cavity with a delivery device loaded with the drug-releasing implant; and b) delivering the drug-releasing implant into the paranasal sinus cavity, wherein the drug-releasing implant comprises a therapeutic amount of mometasone furoate for the treatment of sinusitis and wherein the drug-releasing implant has a first delivery configuration and a second configuration, different from the first, having a viscosity that substantially prevents clearance of the implant from the paranasal sinus cavity.
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31. A method for delivering a drug-releasing implant into a paranasal sinus cavity comprising:
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a) creating access to the paranasal sinus cavity with a delivery device loaded with the drug-releasing implant; and b) delivering the drug-releasing implant into the paranasal sinus cavity, wherein the drug-releasing implant comprises a therapeutic amount of an active agent for the reduction of inflammation and wherein drug-releasing implant has a first delivery configuration and a second configuration, different from the first, having a viscosity that substantially prevents clearance of the implant from the paranasal sinus cavity.
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Specification