Delivery of a stent at an elevated temperature

• US 7,951,185 B1
• Filed: 01/06/2006
• Issued: 05/31/2011
• Est. Priority Date: 01/06/2006
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Royal, Jeffrey David, Abbate, Anthony J.
• Primary Examiner(s): Erezo; Darwin P
• Assistant Examiner(s): Dornbusch; Dianne
• Application Number:
  US11/326,797
• Time in Patent Office: 1,971 Days
• Field of Search: 623/1.1, 623/1.11, 623/1.19, 604/95.05, 604/103.01, 604/113, 604/96.01, 604/97.01, 606/192, 606 27- 31
• US Class Current: 623/1.11
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/9583 Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
• CPC Class Codes: A61F 2210/0004 bioabsorbable

Abstract

Methods and systems of delivering a stent at an elevated temperature are disclosed herein. Methods of delivering a stent include allowing reactants to react within a delivery system exothermically. The heat generated from the exothermic reaction increase a temperature of a stent mounted on a support member. The increase in temperature increases the flexibility of the stent which reduces or eliminates formation of cracks in the stent when it expands. A system can include a first reactant disposed within at least a portion of the support member, a catheter in fluid communication with the support member, or both. The first reactant being disposed in such a way to react exothermically with a second reactant disposed within the delivery system.

Claims

1. A method of delivering a stent mounted on a support member of a delivery system, comprising:

expanding a balloon expandable stent crimped tightly over a balloon on the support member by expanding the balloon, wherein the stent comprises a scaffolding made of a biodegradable polymer with a glass transition temperature greater than body temperature,

wherein a solid coating including a first reactant is on at least a portion of an interior surface of the balloon;

disposing a fluid including a second reactant within the balloon having the solid coating to react with the first reactant included in the solid coating;

allowing the first reactant and the second reactant to react within the balloon, wherein the first and the second reactants react exothermically; and

allowing heat generated from the exothermic reaction to increase a temperature of the balloon expandable stent over the balloon during or after the expansion by the balloon, wherein the increase in temperature increases the flexibility of the stent scaffolding such that formation of cracks in the stent scaffolding upon its expansion is reduced or eliminated.

2. The method of claim 1, wherein the first and second reactants react, before, during, and/or after expansion of the stent.

3. The method of claim 1, further comprising allowing the stent to cool after expansion of the stent.

4. The method of claim 1, wherein the heat from the reaction increases a temperature of the stent at or above a glass transition temperature of the biodegradable polymer.

5. The method of claim 1, further comprising disposing a catalyst in the delivery system to facilitate the reaction.

6. The method of claim 1, wherein the biodegradable polymer is poly(L-lactide).

7. The method of claim 1, wherein first reactant in the coating is dissolved by the fluid so that first reactant can react with the second reactant in the fluid phase.

8. A method of delivering a stent mounted on a support member of a delivery system, comprising:

expanding a balloon expandable stent crimped tightly over a balloon on the support member by expanding the balloon, wherein the stent comprises a scaffolding made of a biodegradable polymer with a glass transition temperature greater than body temperature,

wherein a solid coating including a first reactant and a second reactant is on at least a portion of an interior surface of the balloon;

disposing a fluid into the balloon having the solid coating;

allowing the first reactant and the second reactant to react within the balloon upon exposure of the coating to the fluid, wherein the first and the second reactants react exothermically; and

allowing heat generated from the exothermic reaction to increase a temperature of the balloon expandable stent over the balloon during or after the expansion by the balloon, wherein the increase in temperature increases the flexibility of the stent scaffolding such that formation of cracks in the stent scaffolding upon its expansion is reduced or eliminated.

9. A method of delivering a stent mounted on a catheter of a delivery system, comprising:

expanding a balloon expandable stent crimped tightly over a balloon on the catheter by expanding the balloon, wherein the stent comprises a scaffolding made of a biodegradable polymer with a glass transition temperature greater than body temperature,

wherein a solid coating including a first reactant is on at least a portion of an interior surface of the catheter in fluid communication with the balloon;

disposing a fluid including a second reactant into the delivery system to react with the first reactant included in the solid coating;

allowing the first reactant and the second reactant to react, wherein the first and the second reactants react exothermically; and

allowing heat generated from the exothermic reaction to increase a temperature of the balloon expandable stent over the balloon during or after the expansion by the balloon, wherein the increase in temperature increases the flexibility of the stent scaffolding such that formation of cracks in the stent scaffolding upon its expansion is reduced or eliminated.