Bioabsorbable stent with radiopaque coating

• US 7,951,194 B2
• Filed: 05/22/2007
• Issued: 05/31/2011
• Est. Priority Date: 05/26/2006
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Gueriguian, Vincent J., Gale, David C., Huang, Bin
• Primary Examiner(s): Isabella; David
• Assistant Examiner(s): MATHEW, SEEMA
• Application Number:
  US11/805,357
• Publication Number:
  US 20080009939A1
• Time in Patent Office: 1,470 Days
• Field of Search: 623/1.34, 623/1.38, 623/1.44, 623/1.48, 424/423
• US Class Current: 623/1.44
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Various embodiments of stents with a bioabsorbable body having a coating with a radiopaque layer are disclosed.

Claims

1. A stent comprising:

a bioabsorbable polymer body composed of a scaffolding including a pattern of interconnected struts; and

a coating above the bioabsorbable body, the coating comprising a radiopaque layer including a radiopaque agent dispersed within a second bioabsorbable polymer, wherein the coating comprises a topcoat layer above the radiopaque layer including a third bioabsorbable polymer, the third bioabsorbable polymer comprising a non-water soluble hydrolytically degradable polymer, a water soluble polymer, or a copolymer thereof, wherein the radiopaque agent has the ability to absorb X-rays and allows visualization of the stent with X-ray imaging.

2. A stent comprising:

a bioabsorbable polymer body composed of a scaffolding including a pattern of interconnected struts; and

a coating above the bioabsorbable body, the coating comprising a radiopaque layer including a radiopaque agent dispersed within a second bioabsorbable polymer, wherein the coating further comprises a drug-polymer layer, and wherein the drug-polymer layer is above the radiopaque layer, wherein the radiopaque agent has the ability to absorb X-rays and allows visualization of the stent with X-ray imaging.

3. A stent comprising:

a bioabsorbable polymer body composed of a scaffolding including a pattern of interconnected struts; and

a coating above the bioabsorbable body, the coating comprising a radiopaque layer including a radiopaque agent dispersed within a second bioabsorbable polymer, wherein the coating further comprises a drug-polymer layer, and wherein the radiopaque layer is above the drug-polymer layer, the radiopaque layer configured to reduce a rate of diffusion of a drug in the drug-polymer layer out of the coating, wherein the radiopaque agent has the ability to absorb X-rays and allows visualization of the stent with X-ray imaging.

4. A stent comprising:

a bioabsorbable polymer body composed of a scaffolding including a pattern of interconnected struts; and

a coating above the bioabsorbable body, the coating comprising a radiopaque layer including a radiopaque agent dispersed within a second bioabsorbable polymer, wherein the coating further comprises a drug-polymer layer, and wherein the drug-polymer layer comprises a drug dispersed within a third bioabsorbable polymer, wherein the radiopaque agent has the ability to absorb X-rays and allows visualization of the stent with X-ray imaging.

5. The stent of claim 4, wherein the third bioabsorbable polymer comprises poly(DL-lactide).

6. A stent comprising:

a bioabsorbable polymer body composed of a scaffolding including a pattern of interconnected struts;

a coating above the bioabsorbable body, the coating comprising a radiopaque layer including a bioabsorbable polymer and a radiopaque agent dispersed within the bioabsorbable polymer, wherein a majority of the radiopaque layer is a water soluble contrast agent, and wherein the coating comprises a topcoat layer above the radiopaque layer including a bioabsorbable polymer, the bioabsorbable polymer comprising a non-water soluble hydrolytically degradable polymer or a water soluble polymer, wherein the radiopaque agent has the ability to absorb X-rays and allows visualization of the stent with X-ray imaging.

7. A stent comprising:

a bioabsorbable polymer body composed of a scaffolding including a pattern of interconnected struts;

a coating above the bioabsorbable body, the coating comprising a radiopaque layer including a bioabsorbable polymer and a radiopaque agent dispersed within the bioabsorbable polymer, wherein a majority of the radiopaque layer is a water soluble contrast agent, and wherein the coating comprises a drug-polymer layer above or below the radiopaque layer, the drug-polymer layer including a drug dispersed within a second dissolvable polymer, wherein the radiopaque agent has the ability to absorb X-rays and allows visualization of the stent with X-ray imaging.