Implantable power sources and sensors
First Claim
1. Apparatus for detecting a concentration of a substance in a subject, the apparatus comprising:
- a fluorescence resonance energy transfer (FRET) measurement device; and
a housing adapted to be implanted in the subject, the housing comprisingcells genetically engineered to produce, in situ, a FRET protein having a FRET complex comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding site for the substance.
1 Assignment
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Accused Products
Abstract
A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).
92 Citations
19 Claims
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1. Apparatus for detecting a concentration of a substance in a subject, the apparatus comprising:
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a fluorescence resonance energy transfer (FRET) measurement device; and a housing adapted to be implanted in the subject, the housing comprising cells genetically engineered to produce, in situ, a FRET protein having a FRET complex comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding site for the substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification