Compositions and their uses directed to huntingtin
First Claim
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1. A compound comprising a modified oligonucleotide consisting of 20 to 35 linked nucleosides comprising all 20 nucleobases of SEQ ID NO:
- 118.
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Abstract
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington'"'"'s disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin'"'"'s disease in an individual susceptible to Huntingtin'"'"'s Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
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23 Claims
- 1. A compound comprising a modified oligonucleotide consisting of 20 to 35 linked nucleosides comprising all 20 nucleobases of SEQ ID NO:
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23. A compound comprising a modified oligonucleotide consisting of 20 to 35 linked nucleosides comprising an at least 20 consecutive nucleobase portion complementary to nucleotides 4856-4875 of SEQ ID NO:
- 4, wherein said modified oligonucleotide is at least 90% complementary to SEQ ID NO;
4.
- 4, wherein said modified oligonucleotide is at least 90% complementary to SEQ ID NO;
Specification