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Methods of screening agents for activity using teleosts

  • US 7,951,989 B2
  • Filed: 09/01/2006
  • Issued: 05/31/2011
  • Est. Priority Date: 02/23/1998
  • Status: Expired due to Fees
First Claim
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1. A method of screening an agent in vivo for a toxic activity in the brain or central nervous system (CNS), the method comprising:

  • (a) administering the agent to a teleost;

    (b) detecting cell death, if any, in the brain or CNS of the teleost; and

    (c) comparing the cell death, if any, in the brain or CNS of the agent-treated teleost with cell death, if any in the brain or CNS of an untreated or control teleost, wherein an increase in cell death in the agent-treated teleost compared to the untreated or control teleost identifies the agent as having toxic activity in the brain or CNS.

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