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Optical assay system for intraoperative assessment of tumor margins

  • US 7,952,704 B2
  • Filed: 07/02/2010
  • Issued: 05/31/2011
  • Est. Priority Date: 03/30/2006
  • Status: Active Grant
First Claim
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1. A method for testing a biological sample, the method comprising:

  • placing a biological sample in an interior space defined by a biological sample containment and illumination apparatus having a plurality of frame members positioned with respect to each other to form a single interior volume container for holding a biological sample in an interior region defined by the container, at least one of which includes a plurality of probe receiving locations for receiving a plurality of electromagnetic radiation probes and for positioning the probes with respect to the biological sample while the biological sample is located in the interior region defined by the container to allow simultaneous illumination of plural locations of the biological sample by the probes, and further wherein at least one of the plurality of frame members is translatable with respect to another frame member such that the volume of the interior region can be altered in at least one direction and the at least one translatable frame member can be translated to vary the volume of the interior region so that the biological sample can be placed proximal to the plurality of probes;

    illuminating the biological sample through the probe receiving locations using the probes; and

    detecting electromagnetic radiation reflected from or emitted by the biological sample in response to the illumination.

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