Synchronized X-ray / breathing method and apparatus used in conjunction with a charged particle cancer therapy system

• US 7,953,205 B2
• Filed: 12/15/2009
• Issued: 05/31/2011
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): Glick; Edward J
• Assistant Examiner(s): Artman; Thomas R
• Application Number:
  US12/637,918
• Publication Number:
  US 20100128846A1
• Time in Patent Office: 532 Days
• Field of Search: 378/65, 378/68, 378/69, 600/427, 250/492.3
• US Class Current: 378/69
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1064 for adjusting radiation treatment in response to monitoring
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and/or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and/or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and/or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.

Claims

1. An X-ray apparatus as part of a particle beam cancer therapy system, said particle beam cancer therapy system configured to irradiate a tumor of a patient with a charged particle beam, said apparatus comprising:

a respiration sensor configured to generate a respiration signal, said respiration signal corresponding to a respiration cycle of the patient;

an X-ray generation source located within about forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;

(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam, said apparatus controlled to yield X-ray images at a set point of the respiration cycle by said respiration signal,

a rotatable platform holding the patient,

wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient, and

wherein said X-ray generation source is timed using said respiration signal to produce X-ray images at a set point in the respiration cycle,

wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam,

wherein said X-ray images represent greater than ten rotation positions of said rotatable platform,

wherein the X-ray images combine to form a 3-dimensional image of the tumor, and

wherein said delivery of the charged particle beam at said set point of said respiration cycle occurs in greater than twenty rotation positions of said rotatable platform, wherein ingress energy of said charged particle beam is circumferentially distributed about the tumor.

2. The apparatus of claim 1, wherein said respiration sensor further comprises:

a force meter strapped to the patient'"'"'s chest.

3. The apparatus of claim 1, wherein said respiration sensor further comprises:

a first thermal resistor configurably positioned proximate the patient'"'"'s nose; and

a second thermal resistor positioned both out of an exhalation path of the patient and in the same local room environment as the patient,

wherein said respiration signal is generated using differences between readings from said first thermal resistor and said second thermal resistor.

4. The apparatus of claim 1, further comprising:

a display screen displaying breath control commands to the patient,

wherein said respiration signal is used in generating the breath control command and wherein said breath control command comprises a countdown to when the patient'"'"'s breath is to be held.

5. The apparatus of claim 1, wherein said X-ray generation source comprises a tungsten anode,

wherein said X-ray apparatus further comprises:

an electron generating cathode having a first cross-sectional distance, wherein X-rays are generated by electrons from said cathode striking said tungsten anode;

a focusing control electrode;

accelerating electrodes, said control electrode and said accelerating electrodes located between said cathode and said anode, said focusing control electrode focusing electrons from said first cross-sectional distance to a second cross-sectional distance, wherein said second cross-sectional distance is less than one-half of said first cross-sectional distance;

a magnetic lens; and

a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and said anode, said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet combining to form a substantially parallel electron beam with an electron beam cross-sectional area, wherein a cross-sectional area of said cathode is greater than about eight times that of the electron beam cross-sectional area.

6. The apparatus of claim 5, wherein said substantially parallel electron beam comprises an oblong cross-sectional shape, wherein geometry of said X-ray generation source yields an X-ray beam comprising a nearly circular cross sectional shape when struck by the electron beam having said oblong cross-sectional shape, the X-ray beam running substantially in parallel with the charged particle beam,

wherein said tungsten anode further comprises a liquid cooling element connected to a backside of said tungsten anode,

wherein said X-ray generation source is configured as usable within thirty seconds of subsequent use of the charged particle beam for tumor therapy.

7. The apparatus of claim 1, further comprising a synchrotron, wherein said synchrotron comprises:

a radio-frequency cavity system comprising a first pair of blades for inducing betatron oscillation;

a foil yielding slowed charged particles from particles in the charged particle beam having sufficient betatron oscillation to traverse said foil, wherein the slowed charged particles pass through a second pair of blades having an extraction voltage directing the charged particles out of said synchrotron through a Lamberson extraction magnet,

wherein said radio-frequency cavity system for inducing betatron oscillation is timed using said respiration signal.

8. A method coordinating an X-ray system and a particle beam cancer therapy system, said particle beam cancer therapy system irradiating a tumor of a patient with a charged particle beam during use, said method comprising the steps of:

generating X-rays with an X-ray generation source located within forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;

(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam;

accelerating the charged particle beam with a synchrotron;

generating a respiration signal using a respiration sensor, said respiration signal corresponding to a respiration cycle of the patient;

rotating the patient with a rotatable platform, wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient; and

controlling delivery the charged particle beam from said synchrotron to the tumor at a set point in the respiration cycle using the respiration signal,

wherein said delivery of said charged particle beam at said set point of the respiration cycle occurs in greater than four rotation positions of said rotatable platform,

wherein the tumor is targeted using X-ray images collected using X-rays from said X-ray generation source, and

wherein the X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam.

9. The method of claim 8, further comprising the steps of:

generating electrons with a cathode, said cathode having a first cross-sectional distance, wherein the X-rays are generated by the electrons from said cathode striking a tungsten anode;

focusing the electrons from said first cross-sectional distance to a second cross-sectional distance with a focusing control electrode; and

accelerating the electrons with accelerating electrodes, said focusing control electrode and said accelerating electrodes located between said cathode and said anode.

10. The method of claim 9, further comprising the steps of:

forming a substantially parallel electron beam from the electrons with said control electrode, said accelerating electrodes, a magnetic lens, and a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and said anode, wherein the electron beam comprises a cross-sectional area, wherein a cross-sectional area of said cathode is greater than about eight times that of the electron beam cross-sectional area; and

forming a substantially circular cross-section X-ray beam, wherein said substantially parallel electron beam comprises an oblong cross-sectional shape, wherein geometry of said X-ray generation source yields the substantially circular cross section X-ray when struck by the electron beam having said oblong cross-sectional shape, the X-ray beam running substantially in parallel with the charged particle beam.

11. The method of claim 10, further comprising the steps of:

cooling said tungsten anode with a cooling element connected to a backside of said tungsten anode;

using said X-ray generation source within thirty seconds of subsequent use of the charged particle beam for tumor therapy;

rotating said rotatable platform through about three hundred sixty degrees during an irradiation period of the patient; and

combining said images to form a three-dimensional image of the tumor.

12. The method of claim 8, further comprising the step of:

producing multi-field images of the tumor, wherein the multi-field images are collected by rotating a patient holding platform between collection of X-ray images,

wherein the X-ray images occur in at least ten rotation positions of said platform,

wherein the X-ray images are created using X-rays from said X-ray generation source.

13. The method of claim 12, wherein said respiration sensor further comprises:

a force meter strapped to the patient'"'"'s chest.

14. The method of claim 12, further comprising the steps of:

positioning a first thermal resistor proximate the patient'"'"'s nose;

positioning a second thermal resistor both out of an exhalation path of the patient and in the same local room environment as said rotatable platform and the patient;

generating said respiration signal using differences between readings from said first thermal resistor and said second thermal resistor; and

displaying breath control commands to the patient on a display screen.

15. The method of claim 14, further comprising the steps of:

generating said breath control command using said respiration signal, wherein said breath control command comprises a visually displayed countdown to when the patient'"'"'s breath is to be held; and

circumferentially distributing ingress energy of said charged particle beam about the tumor by delivering the charged particle beam at said set point of said respiration in greater than twenty rotation positions of said rotatable platform.

16. The method of claim 8, wherein said synchrotron further comprises:

a radio-frequency cavity system comprising a first pair of blades for inducing betatron oscillation; and

a foil yielding slowed charged particles from particles in the charged particle beam having sufficient betatron oscillation to traverse said foil; and

wherein said method further comprises the steps of;

directing the charged particles out of said synchrotron through a Lamberson extraction magnet after the slowed charged particles pass through a second pair of blades having an extraction voltage; and

timing said radio-frequency cavity system for inducing betatron oscillation to said respiration signal.

17. The method of claim 16, wherein said synchrotron further comprises:

exactly four, ninety degree, turning sections; and

no quadrupole magnets about the circulating path of the synchrotron, wherein each of said four, ninety degree, turning sections comprises four magnets, wherein each of said four turning magnets comprise two beveled focusing edges.

18. The method of claim 8, further comprising the step of:

converting a negative ion beam at a converting foil into the charged particle beam, wherein an injection system comprising a magnetic material at least partially contained in a plasma chamber yields the negative ion beam.