Synchronized X-ray / breathing method and apparatus used in conjunction with a charged particle cancer therapy system
First Claim
1. An X-ray apparatus as part of a particle beam cancer therapy system, said particle beam cancer therapy system configured to irradiate a tumor of a patient with a charged particle beam, said apparatus comprising:
- a respiration sensor configured to generate a respiration signal, said respiration signal corresponding to a respiration cycle of the patient;
an X-ray generation source located within about forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;
(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam, said apparatus controlled to yield X-ray images at a set point of the respiration cycle by said respiration signal,a rotatable platform holding the patient,wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient, andwherein said X-ray generation source is timed using said respiration signal to produce X-ray images at a set point in the respiration cycle,wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam,wherein said X-ray images represent greater than ten rotation positions of said rotatable platform,wherein the X-ray images combine to form a 3-dimensional image of the tumor, andwherein said delivery of the charged particle beam at said set point of said respiration cycle occurs in greater than twenty rotation positions of said rotatable platform, wherein ingress energy of said charged particle beam is circumferentially distributed about the tumor.
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Abstract
The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and/or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and/or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and/or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.
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Citations
18 Claims
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1. An X-ray apparatus as part of a particle beam cancer therapy system, said particle beam cancer therapy system configured to irradiate a tumor of a patient with a charged particle beam, said apparatus comprising:
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a respiration sensor configured to generate a respiration signal, said respiration signal corresponding to a respiration cycle of the patient; an X-ray generation source located within about forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;
(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam, said apparatus controlled to yield X-ray images at a set point of the respiration cycle by said respiration signal,a rotatable platform holding the patient, wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient, and wherein said X-ray generation source is timed using said respiration signal to produce X-ray images at a set point in the respiration cycle, wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam, wherein said X-ray images represent greater than ten rotation positions of said rotatable platform, wherein the X-ray images combine to form a 3-dimensional image of the tumor, and wherein said delivery of the charged particle beam at said set point of said respiration cycle occurs in greater than twenty rotation positions of said rotatable platform, wherein ingress energy of said charged particle beam is circumferentially distributed about the tumor. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method coordinating an X-ray system and a particle beam cancer therapy system, said particle beam cancer therapy system irradiating a tumor of a patient with a charged particle beam during use, said method comprising the steps of:
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generating X-rays with an X-ray generation source located within forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position;
(1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam;accelerating the charged particle beam with a synchrotron; generating a respiration signal using a respiration sensor, said respiration signal corresponding to a respiration cycle of the patient; rotating the patient with a rotatable platform, wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period of the patient; and controlling delivery the charged particle beam from said synchrotron to the tumor at a set point in the respiration cycle using the respiration signal, wherein said delivery of said charged particle beam at said set point of the respiration cycle occurs in greater than four rotation positions of said rotatable platform, wherein the tumor is targeted using X-ray images collected using X-rays from said X-ray generation source, and wherein the X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification