Controlled vapor deposition of biocompatible coatings for medical devices

• US 7,955,704 B2
• Filed: 11/03/2009
• Issued: 06/07/2011
• Est. Priority Date: 05/05/2005
• Status: Active Grant

• Current Assignee: Johnson & Johnson Surgical Vision, Inc. (Johnson & Johnson)
• Original Assignee: Applied Microstructures, Inc. (KLA Corporation)
• Inventors: Kobrin, Boris, Yi, Richard, Lowery, Michael D., Hoffmann, Laurent, Chinn, Jeffrey, Nowak, Romuald
• Primary Examiner(s): NAKARANI, DHIRAJLAL S
• Application Number:
  US12/611,639
• Publication Number:
  US 20100137984A1
• Time in Patent Office: 581 Days
• Field of Search: 428/333, 428/451
• US Class Current: 428/451
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 40/00 Manufacture or treatment of nanostructures
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: Y10T 428/261 In terms of molecular thickness or light wave length
• CPC Class Codes: Y10T 428/31667 Next to addition polymer from unsaturated monomers, or aldehyde or ketone condensation product

Abstract

An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.

Claims

1. An intraocular lens having a coating comprising a polyethylene glycol polymer having a plurality of monomers of the structure of Formula 1:

2. The intraocular lens of claim 1, wherein the coating is vapor deposited by the method comprising the steps of:

a) exposing a surface of the intraocular lens to an oxygen-comprising plasma in a processing chamber which is at subatmospheric pressure;

b) subsequently, without exposure of said oxygen-comprising plasma treated surface to ambient conditions which contaminate or react with said plasma treated surface, exposing said surface to a silicon chloride containing vapor in the presence of moisture, to form a hydrophilic silicon oxide layer on said surface; and

c) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said hydrophilic silicon oxide layer, exposing said silicon oxide layer to the polyethylene glycol polymer having a plurality of monomers of the structure of Formula 1 to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer.

3. The intraocular lens of claim 2, wherein the method further comprises the steps of:

d) repeating steps a) through c), or repeating step b) through c), or repeating step c) a nominal number of times, without exposing said substrate to ambient conditions.

4. The intraocular lens of claim 2 wherein said monomer has the structure of Formula 2:

5. The intraocular lens of claim 1, wherein the coating is vapor deposited by the method comprising the steps of:

a) exposing a surface of the intraocular lens to an silicon chloride containing vapor in the presence of moisture, to form a hydrophilic SiO₂, layer on the surface; and

b) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said SiO₂, layer, exposing said SiO₂ layer to the polyethylene glycol polymer having a plurality of monomers of the structure of Formula 1 to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer.

6. The intraocular lens of claim 5, wherein the method further comprising the steps of:

c) repeating steps a) through b), or repeating step b) a nominal number of times, without exposing said substrate to ambient conditions.

7. The intraocular lens of claim 1 wherein R₁, R₂ and R₃ all comprise methoxy groups.