Dried and agglomerated hyaluronic acid product
First Claim
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1. A product comprising a hyaluronic acid or a salt thereof, which product is dried and agglomerated and has:
- (a) a moisture content of less than 5%;
(b) a particle size, the 50 percentile of which, is between 180 and 1000 microns, as determined by laser diffraction measurement of the particles suspended in isopropanol;
(c) a dispersibility of less than 30 minutes in an aqueous solvent; and
(d) a solubility of less than 60 minutes in an aqueous solvent;
wherein the hyaluronic acid is not crosslinked and has a molecular weight up to 1,800,000 Da.
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Abstract
The present invention relates to products comprising hyaluronic acid or a salt thereof, which product is dried and agglomerated as defined herein, various compositions and articles comprising the product or compositions of the invention, methods of producing the product of the invention, and uses thereof.
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Citations
26 Claims
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1. A product comprising a hyaluronic acid or a salt thereof, which product is dried and agglomerated and has:
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(a) a moisture content of less than 5%; (b) a particle size, the 50 percentile of which, is between 180 and 1000 microns, as determined by laser diffraction measurement of the particles suspended in isopropanol; (c) a dispersibility of less than 30 minutes in an aqueous solvent; and (d) a solubility of less than 60 minutes in an aqueous solvent; wherein the hyaluronic acid is not crosslinked and has a molecular weight up to 1,800,000 Da. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification