Process for the preparation of aniline-derived thyroid receptor ligands

• US 7,956,214 B2
• Filed: 06/15/2009
• Issued: 06/07/2011
• Est. Priority Date: 11/02/2001
• Status: Expired due to Fees

• Current Assignee: Bristol-Myers Squibb Company, Karo Pharma AB
• Original Assignee: Bristol-Myers Squibb Company, Karo Pharma AB
• Inventors: Chidambaram, Ramakrishnan, Kant, Joydeep, Ghosh, Arun, Weaver, Raymond E., Yu, Jurong
• Primary Examiner(s): Puttlitz; Karl J
• Application Number:
  US12/456,313
• Publication Number:
  US 20090326263A1
• Time in Patent Office: 722 Days
• Field of Search: None
• US Class Current: 562/30
• CPC Class Codes: C07C 201/12 by reactions not involving the formation of nitro groups
• CPC Class Codes: C07C 205/12 the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
• CPC Class Codes: C07C 205/37 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 205/38 the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. nitrodiphenyl ethers
• CPC Class Codes: C07C 205/43 to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
• CPC Class Codes: C07C 213/02 by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
• CPC Class Codes: C07C 217/90 the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
• CPC Class Codes: C07C 231/02 from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
• CPC Class Codes: C07C 233/25 having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• CPC Class Codes: C07C 309/24 of a carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 309/65 of a saturated carbon skeleton
• CPC Class Codes: C07C 45/00 Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
• CPC Class Codes: C07C 47/575 containing ether groups, groups, groups, or groups

Abstract

Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.

Claims

1. A compound selected from the group consisting of compounds of formula A-II,

2. The compound according to claim 1, wherein said compound is hydroxy-(3-isopropyl-4-methoxyphenyl)methanesulfonic acid, sodium salt.