Methods for identifying neuronal spikes
First Claim
1. A method of identifying neuronal spikes comprising the steps of:
- a. obtaining amplitude readings sampled over time from an electrode situated within tissue;
b. identifying series of successive readings having at least one of(1) continuously increasing amplitude, and(2) continuously decreasing amplitude, each such series of readings representing a spike candidate;
c. identifying spikes within the spike candidates, the spikes being chosen from the spike candidates having greatest amplitude; and
d. performing at least one of the steps of;
(1) placing a therapeutic electrode within the tissue, and(2) delivering electrical stimulation from a therapeutic electrode to the tissue, in dependence on the identified spikes.
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Abstract
A method for identifying neuronal spikes (extracellular action potentials) is described wherein measured microelectrode readings from tissue are reviewed to identify spikes (successive readings having prolonged rises and/or falls). The frequency of such spikes as a function of their amplitude assumes a bimodal distribution wherein higher amplitude spikes represent neuronal spikes (signal) and lower amplitude spikes represent noise, and thus the higher amplitude spikes can be assumed to be neuronal spikes. Neuronal spikes from the same neuron can then be assumed to have substantially the same waveform shape and period, with the only significant difference between them being the scaling of their amplitudes (i.e., the amplitudes of spikes from the same neuron tend to be proportionate at any given time along their period). Thus, by testing identified neuronal spikes for matching timing and for proportional amplitudes, the neuronal spikes may further be identified as coming from the same or different neurons.
45 Citations
27 Claims
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1. A method of identifying neuronal spikes comprising the steps of:
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a. obtaining amplitude readings sampled over time from an electrode situated within tissue; b. identifying series of successive readings having at least one of (1) continuously increasing amplitude, and (2) continuously decreasing amplitude, each such series of readings representing a spike candidate; c. identifying spikes within the spike candidates, the spikes being chosen from the spike candidates having greatest amplitude; and d. performing at least one of the steps of; (1) placing a therapeutic electrode within the tissue, and (2) delivering electrical stimulation from a therapeutic electrode to the tissue, in dependence on the identified spikes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of identifying neuronal spikes comprising the steps of:
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a. obtaining amplitude readings sampled over time from an electrode situated within tissue; b. identifying series of readings wherein a positive-amplitude peak is followed by a negative-amplitude valley, each such series of readings representing a spike candidate; c. determining the amplitude distribution of the spike candidates; d. identifying the amplitude within the distribution at which the highest proportion of spike candidates are clustered, this amplitude representing a noise peak; e. selecting as spikes at least some of the spike candidates having amplitudes greater than the amplitude of the noise peak; and d. performing at least one of the steps of; (1) placing a therapeutic electrode within the tissue, and (2) delivering electrical stimulation from a therapeutic electrode to the tissue, in dependence on the spikes. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method of identifying neuronal spikes comprising the steps of:
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a. obtaining amplitude readings sampled over time from an electrode situated within tissue, the amplitude readings defining spikes; b. grouping at least some of the spikes, each group having; (1) at least substantially identical time between the amplitude maxima and amplitude minima of the spikes therein, (2) proportionate amplitude maxima between the spikes therein, and (3) proportionate amplitude minima between the spikes therein; and d. performing at least one of the steps of; (1) placing a therapeutic electrode within the tissue, and (2) delivering electrical stimulation from a therapeutic electrode to the tissue, in dependence on the grouped spikes. - View Dependent Claims (23, 24, 25, 26, 27)
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Specification