Non-invasive cardiac potentiation therapy

• US 7,957,799 B2
• Filed: 04/30/2007
• Issued: 06/07/2011
• Est. Priority Date: 04/30/2007
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sullivan, Joseph L., Walker, Robert G., Deno, D. Curtis, Chapman, Fred W., Havel, William J.
• Primary Examiner(s): Patel; Niketa I
• Assistant Examiner(s): HOLMES, REX R
• Application Number:
  US11/742,063
• Publication Number:
  US 20080269818A1
• Time in Patent Office: 1,499 Days
• Field of Search: 607 2- 7, 607 23- 27
• US Class Current: 607/5
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
• CPC Class Codes: A61N 1/3625 External stimulators
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3925 Monitoring; Protecting

Abstract

An external cardiac medical device for delivering Cardiac Potentiation Therapy (CPT). Techniques used with the device include initial diagnosis of the patient, delivery of the CPT, and configuration of the external device, so that CPT can be effectively and efficiently provided. In particular, these techniques include initially determining whether a patient should receive CPT, how to set the coupling interval for delivering CPT, how to configure the external medical device to deliver CPT stimulation pulses while not adversely affecting the device'"'"'s ability to sense a patient'"'"'s cardiac parameters and/or signals.

Claims

1. An external cardiac medical device for delivering cardiac potentiation therapy to a patient, comprising:

a plurality of electrodes adapted for attachment to external body surfaces of the patient and configured for delivering therapy to the patient;

a controller electrically connected to the plurality of electrodes; and

a therapy delivery system electrically connected to the plurality of electrodes, the therapy delivery system configured for delivery of defibrillation shocks to the patient and for delivering electrical stimulation pulses to the patient over a series of cardiac cycles to increase the patient'"'"'s cardiac output, the controller configured for triggering the delivery of the electrical stimulation pulses following an estimation that cardiac output of the patient is insufficient, the estimation provided via non-invasive assessment of cardiac condition of the patient by one or more of the controller or an operator, the therapy delivery system directed by the controller to deliver the electrical stimulation pulses outside refractory periods of the cardiac cycles;

wherein the non-invasive assessment of the patient'"'"'s cardiac condition involves consideration of cardiac information of the patient or lack thereof, the cardiac information attained non-invasively, and wherein the cardiac information comprises one or more of cardiac signals and hemodynamic parameters;

wherein the cardiac information comprises one or more measurements supplied by the controller, wherein the one or more measurements comprise one or more of ventricular fibrillation duration and one or more patient pulse detection measurements; and

wherein the ventricular fibrillation duration comprises a time period beginning at activation of the external cardiac medical device and ending at delivery of the defibrillation shocks, and wherein a measured time period greater than two minutes comprises a trigger for the delivery of the electrical stimulation pulses.

2. An external cardiac medical device according to claim 1, wherein the therapy delivery system is further configured for delivering pacing pulses to the patient and, the delivery of the electrical stimulation pulses comprises delivery of each of the electrical stimulation pulses paired with an intrinsic event or a paced event within the series of cardiac cycles.

3. An external cardiac medical device according to claim 2, wherein the cardiac information further comprises one or more measurements supplied by the operator, wherein the one or more measurements comprise one or more of pulse and blood pressure.

4. An external cardiac medical device according to claim 2, wherein the one or more pulse detection measurements further comprise measurement of QRS complexes of an ECG signal, wherein a succession of wide QRS complexes comprises a trigger for the delivery of the electrical stimulation pulses.

5. An external cardiac medical device according to claim 2, wherein the controller is configured for interpreting the cardiac information in order to direct the therapy delivery system to deliver the electrical stimulation pulses outside the refractory periods of the cardiac cycles.

6. An external cardiac medical device according to claim 2, wherein the plurality of electrodes comprises a single pair of electrodes, the single pair of electrodes having both therapy and monitoring functionality.

7. An external cardiac medical device according to claim 6, wherein the electrical stimulation pulses comprise biphasic pulses.

8. An external cardiac medical device according to claim 6, wherein the electrodes of the single pair each have segmented pads, wherein each segmented pad has at least one conductive area for therapy and at least one conductive area for monitoring.

9. An external cardiac medical device according to claim 1, wherein the electrical stimulation pulses comprise a first string of pulses either having gradually increasing or gradually decreasing amplitudes followed by a second string of pulses having an optimal amplitude, the optimal pulse amplitude benefiting the patient yet without delivering excessive current to the patient.

10. An external cardiac medical device for delivering cardiac potentiation therapy to a patient, comprising:

a plurality of electrodes adapted for attachment to external body surfaces of the patient and configured for delivering therapy to the patient;

a controller electrically connected to the plurality of electrodes; and

a therapy delivery system electrically connected to the plurality of electrodes, the therapy delivery system configured for delivery of defibrillation shocks to the patient and for delivering electrical stimulation pulses to the patient over a series of cardiac cycles to increase the patient'"'"'s cardiac output, the controller configured for triggering the delivery of the electrical stimulation pulses following delivery of one or more defibrillation shocks to the patient and an estimation that cardiac output of the patient is insufficient, the therapy delivery system directed by the controller to deliver the electrical stimulation pulses outside refractory periods of the cardiac cycles;

wherein the estimation comprises measurement of ventricular fibrillation duration and wherein the ventricular fibrillation duration comprises a measured time period beginning at activation of the external cardiac medical device and ending at delivery of the defibrillation shocks.

11. A device according to claim 10 wherein the measured time period is greater than two minutes.

12. A device according to claim 11 wherein the therapy delivery system is further configured for delivering pacing pulses to the patient and, the delivery of the electrical stimulation pulses comprises delivery of each of the electrical stimulation pulses paired with an intrinsic event or a paced event within the series of cardiac cycles.

13. A device for delivering cardiac potentiation therapy to a patient, comprising:

a plurality of electrodes adapted for attachment to the body of the patient and configured for delivering therapy to the patient;

a controller electrically connected to the plurality of electrodes; and

a therapy delivery system electrically connected to the plurality of electrodes, the therapy delivery system configured for delivery of defibrillation shocks to the patient and for delivering electrical stimulation pulses to the patient over a series of cardiac cycles to increase the patient'"'"'s cardiac output, the controller configured for triggering the delivery of the electrical stimulation pulses following delivery of one or more defibrillation shocks to the patient and an estimation that cardiac output of the patient is insufficient, the therapy delivery system directed by the controller to deliver the electrical stimulation pulses outside refractory periods of the cardiac cycles;

wherein the estimation comprises measurement of ventricular fibrillation duration and wherein the ventricular fibrillation duration comprises a measured time period beginning at activation of the device and ending at delivery of the defibrillation shocks.

14. A device according to claim 13 wherein the therapy delivery system is further configured for delivering pacing pulses to the patient and, the delivery of the electrical stimulation pulses comprises delivery of each of the electrical stimulation pulses paired with an intrinsic event or a paced event within the series of cardiac cycles.