Gastric electrical stimulation with therapy window anti-desensitization feature

• US 7,957,807 B2
• Filed: 09/24/2008
• Issued: 06/07/2011
• Est. Priority Date: 10/01/2007
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Yuan, Charlene X., Pivotto, Luiz Geraldo, Starkebaum, Warren L., Maude-Griffin, Roland C.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US12/236,852
• Publication Number:
  US 20090088818A1
• Time in Patent Office: 986 Days
• Field of Search: 607/40, 607/133
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.

Claims

1. A method comprising delivering electrical stimulation therapy to a gastrointestinal organ of a patient for a first period of time, wherein the first period of time is selected to produce a desired therapeutic effect for a second period of time that extends at least in part beyond an end of the first period of time, and wherein the desired therapeutic effect includes a change in gastric muscle tone indicated by a degree of gastric distention.

2. The method of claim 1, wherein the second period of time is greater than the first period of time.

3. The method of claim 1, wherein the first period of time is selected as approximately a minimum period of time sufficient to produce the desired therapeutic effect for the second period of time.

4. The method of claim 1, wherein the degree of gastric distention corresponds to a percentage increase in gastric volume.

5. The method of claim 1, wherein delivering electrical stimulation therapy to a gastrointestinal organ of a patient for a first period of time comprises delivering electrical stimulation therapy to one of a stomach or a small intestine of the patient.

6. The method of claim 1, further comprising receiving an instruction from an external programmer to generate the electrical stimulation therapy for the first period of time.

7. A gastric electrical stimulation device comprising:

means for generating electrical stimulation therapy for a first period of time; and

means for delivering the electrical stimulation therapy to a gastrointestinal organ of a patient,

wherein the first period of time is selected to produce a desired therapeutic effect for a second period of time that extends at least in part beyond an end of the first period of time, and

wherein the desired therapeutic effect includes a change in gastric muscle tone indicated by a degree of gastric distention.

8. The device of claim 7, wherein the second period of time is greater than the first period of time.

9. The device of claim 7, wherein the first period of time is selected as approximately a minimum period of time sufficient to produce the desired therapeutic effect for the second period of time.

10. The device of claim 7, wherein the degree of gastric distention corresponds to a percentage increase in gastric volume.

11. The device of claim 7, wherein the gastrointestinal organ is one of a stomach or a small intestine of the patient, and the electrical stimulation is configured to produce the desired therapeutic effect in the stomach or the small intestine.

12. The device of claim 7, further comprising means for receiving an instruction from an external programmer to generate the electrical stimulation therapy for the first period of time.

13. A gastric electrical stimulation device comprising:

an electrical stimulation generator that generates electrical stimulation therapy for a first period of time; and

one or more implantable electrodes coupled to deliver the electrical stimulation therapy to a gastrointestinal organ of a patient,

wherein the first period of time is selected to produce a desired therapeutic effect for a second period of time that extends at least in part beyond an end of the first period of time, and

wherein the desired therapeutic effect includes a change in gastric muscle tone indicated by a degree of gastric distention.

14. The device of claim 13, wherein the second period of time is greater than the first period of time.

15. The device of claim 13, wherein the first period of time is selected as approximately a minimum period of time sufficient to produce the desired therapeutic effect for the second period of time.

16. The device of claim 13, wherein the degree of gastric distention corresponds to a percentage increase in gastric volume.

17. The device of claim 13, wherein the gastrointestinal organ is one of a stomach or a small intestine of the patient, and the electrical stimulation is configured to produce the desired therapeutic effect in the stomach or the small intestine.

18. The device of claim 13, further comprising a telemetry interface that receives an instruction from an external programmer to generate the electrical stimulation therapy for the first period of time.

19. An external programmer device for a gastric electrical stimulator, the programmer comprising a processor that controls the electrical stimulator to generate electrical stimulation therapy for a first period of time for delivery to a gastrointestinal organ of a patient, wherein the first period of time is selected to produce a desired therapeutic effect for a second period of time that extends at least in part beyond an end of the first period of time, and wherein the desired therapeutic effect includes a change in gastric muscle tone indicated by a degree of gastric distention.

20. The device of claim 19, wherein the second period of time is greater than the first period of time.

21. The device of claim 19, wherein the first period of time is selected as approximately a minimum period of time sufficient to produce the desired therapeutic effect for the second period of time.

22. The device of claim 19, wherein the degree of gastric distention corresponds to a percentage increase in gastric volume.

23. The device of claim 19, wherein the gastrointestinal organ is one of a stomach or a small intestine of the patient, and the electrical stimulation is configured to produce the desired therapeutic effect in the stomach or the small intestine.

24. The device of claim 19, further comprising a telemetry interface that transmits the instruction to cause the electrical stimulation generator to generate the electrical stimulation therapy for the first period of time.

25. A method comprising:

selecting a first period of time, for delivery of electrical stimulation therapy to a gastrointestinal organ of a patient, sufficient to produce a desired therapeutic effect for a second period of time that extends at least in part beyond an end of the first period of time; and

controlling an electrical stimulator to deliver the electrical stimulation therapy to the gastrointestinal organ of the patient for the first period of time, wherein the desired therapeutic effect includes a change in gastric muscle tone indicated by a degree of gastric distention.

26. The method of claim 25, wherein the first period of time is selected as approximately a minimum period of time sufficient to produce the desired therapeutic effect for the second period of time.