Dry powder inhaler

• US 7,958,890 B2
• Filed: 12/04/2008
• Issued: 06/14/2011
• Est. Priority Date: 02/01/2000
• Status: Expired due to Fees

• Current Assignee: Quadrant Technologies Limited (Vectura Group Ltd.)
• Original Assignee: Quadrant Technologies Limited (Vectura Group Ltd.)
• Inventors: Ganem, Charles F., Chen, Jeffrey, Ligotke, Michael, Gieschen, Andrew W., Greenspan, Bernard
• Primary Examiner(s): Douglas; Steven O
• Assistant Examiner(s): OSTRUP, CLINTON T
• Application Number:
  US12/328,657
• Publication Number:
  US 20090084380A1
• Time in Patent Office: 922 Days
• Field of Search: 128/203.15, 128/203.14, 128/203.19, 128/203.21, 128/203.22, 128/203.23, 128/200.12
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/0008 rotating by airflow
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0043 Non-destructive separation of the package, e.g. peeling
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/43 making noise when used correctly
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: A61M 2206/18 Coaxial flows, e.g. one flow within another

Abstract

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.

Claims

1. A unit dose dry powder inhaler, comprising:

a housing having an inlet portion;

a platform on an exterior surface of the inlet portion of the housing;

a unit dose container on the platform of the housing, with the unit dose container containing a unit dose of a dry powder;

a dispersion chamber in the housing;

an inlet flow path in the housing from the unit dose container to the dispersion chamber;

a mouthpiece on the housing;

an outlet tube in the housing providing an outlet flow path from the dispersion chamber into the mouthpiece, and with the outlet tube extending into the mouthpiece;

at least one sheath air inlet providing a sheath air flow path into the mouthpiece; and

the outlet flow path and the sheath air flow path coming together within the mouthpiece.

2. The dry powder inhaler of claim 1 with the sheath air inlet oriented in a direction substantially perpendicular to the outlet tube.

3. The dry powder inhaler of claim 1 with the sheath air inlet leading into an annular sheath air flow region surrounding the outlet tube.

4. The dry powder inhaler of claim 1 with the sheath air inlet extending radially inwardly relative to the mouthpiece and forming a first section of the sheath air flow path, and further comprising a second section of the sheath air flow path extending generally perpendicular to the first section and generally parallel to the mouthpiece.

5. The inhaler of claim 1 further comprising:

the dispersion chamber having an open central interior area;

a curved outer wall in the dispersion chamber forming a bead race in the dispersion chamber; and

at least one bead in the dispersion chamber, with the bead having a diameter or characteristic dimension of at least 50 to 90% of an interior height of the dispersion chamber.

6. The inhaler of claim 5 wherein the bead race has a radius of curvature greater than a radius of curvature of the bead.

7. The inhaler of claim 6 wherein the dispersion chamber has a flat bottom surface and a flat top surface adjoining the bead race.

8. The inhaler of claim 1 wherein the dispersion chamber is disk-shaped and has an inner diameter greater than the largest inside diameter of the mouthpiece.

9. The inhaler of claim 1 further comprising at least one bead in the dispersion chamber and means for retaining the at least one bead in the dispersion chamber.

10. The inhaler of claim 1 further comprising at least one bead in the dispersion chamber and wherein the at least one bead has a diameter or characteristic dimension which allows it to move around chaotically in the dispersion chamber when a patient inhales on the outlet.

11. The inhaler of claim 1 further comprising a dose platform fixed in place on the housing adjacent to the inlet, for holding the unit dose container.

12. The inhaler of claim 1 further including at least one bead in the dispersion chamber and wherein the dispersion chamber has a characteristic dimension that is from 4 to 20 times greater than a characteristic dimension of the at least one bead.

13. The dry powder inhaler of claim 1 adapted to cause about 30-95% of the total airflow moving through inhaler during use to move through the outlet flow path, and with the balance moving through the sheath air flow path.

14. The dry powder inhaler of claim 1 with the at least one sheath air inlet in the mouthpiece, and with the sheath air flow path having a length less than the length of the mouthpiece.

15. The dry powder inhaler of claim 14 with the at least one sheath air inlet extending through an external wall of the mouthpiece, for supplying sheath air from outside of the inhaler directly into the mouthpiece.

16. The inhaler of claim 1 further comprising an exit tube having a round outside surface surrounded by inner walls of the mouthpiece shaped in an ellipse or an oval.

17. The inhaler of claim 16 with the exit tube offset from a centerline of the mouthpiece.

18. The inhaler of claim 1 with the outlet tube attached over an open central area of the dispersion chamber.

19. The inhaler of claim 1 further comprising a disk-shaped dispersion chamber having generally parallel top and bottom surfaces, and with the inlet flow path comprising a single opening into the dispersion chamber substantially parallel to the top and bottom surfaces.

20. A unit dose dry powder inhaler, comprising:

a housing having an inlet portion;

a platform on an exterior surface of the inlet portion;

a unit dose container containing a unit dose of a dry powder on the platform;

a dispersion chamber;

a mouthpiece;

a powder flow path connecting from the unit dose container into the dispersion chamber, and from the dispersion chamber into the mouthpiece, for moving powder laden air from adjacent the unit dose container to the dispersion chamber and into the mouthpiece; and

a sheath air flow path between an outer wall of the annular ring and an inner wall of the mouthpiece, for moving ambient air into the mouthpiece;

with the powder flow path and the sheath air flow path combining together within the mouthpiece.

21. The dry powder inhaler of claim 20 with the dry powder source comprising a unit dose container on a dose platform fixed in place relative to the dispersion chamber, and a dose opening in the dose platform to allow dry powder to move from the unit dose container on the dose platform, through the dose opening and into the powder flow path.

22. The dry powder inhaler of claim 20 further comprising a bead storage compartment attached to the dispersion chamber;

one or more beads in the bead storage compartment, and a retainer holding the beads in the bead storage compartment until the inhaler is used.

23. The dry powder inhaler of claim 20 further comprising a plurality of outlets between the dispersion chamber and the mouthpiece.

24. A unit dose dry powder inhaler, comprising:

an inhaler housing having an inlet portion;

a platform on an exterior surface of the inlet portion of the housing;

a unit dose container on the housing;

a dispersion chamber within the housing;

an inlet flow path leading from a position in the inhaler adjacent to the unit dose container to the dispersion chamber;

a mouthpiece on the housing;

an outlet tube forming an outlet flow path from the dispersion chamber into the mouthpiece; and

at least one sheath air inlet providing a sheath air flow path into the mouthpiece.

25. A unit dose dry powder inhaler, comprising:

a housing having an inlet portion;

a platform on an exterior surface of the inlet portion of the housing;

a unit dose container on the platform, with the unit dose container containing a dose of a dry powder;

a disk-shaped dispersion chamber in the housing having an inner diameter greater than the largest inside diameter of the mouthpiece;

an inlet flow path in the housing connecting into the dispersion chamber;

a mouthpiece on the housing;

an outlet tube in the housing providing an outlet flow path from the dispersion chamber into the mouthpiece, and with a front end of the outlet tube extending into the mouthpiece and a back end of the outlet tube extending into the dispersion chamber;

a sheath air flow path for moving ambient air into the mouthpiece, and including a sheath air inlet forming a first sheath air flow path section extending radially inwardly relative to a longitudinal axis of the mouthpiece and also forming a second sheath air flow path section adjoining with the first sheath air flow path section and extending generally perpendicular to the first sheath air flow path section and generally parallel to the axis of the mouthpiece, and with the combined length of the first and second sheath air flow paths less than the length of the mouthpiece; and

the outlet flow path and the sheath air flow path coming together within the mouthpiece.