Methods and techniques to measure, map and correlate ocular micro-movement and ocular micro-tremor (OMT) signals with cognitive processing capabilities in ADD/ADHD individuals

• US 7,959,578 B2
• Filed: 01/29/2009
• Issued: 06/14/2011
• Est. Priority Date: 02/01/2008
• Status: Expired due to Fees

• Current Assignee: Martin Lonky
• Original Assignee: Martin Lonky
• Inventors: Lonky, Martin L.
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): NGUYEN, HUONG Q
• Application Number:
  US12/362,046
• Publication Number:
  US 20090198148A1
• Time in Patent Office: 866 Days
• Field of Search: 600/558, 600/595, 382/117, 606/4, 351/209
• US Class Current: 600/558
• CPC Class Codes: A61B 3/113 for determining or recording eye movement
• CPC Class Codes: A61B 5/1101 Detecting tremor
• CPC Class Codes: A61B 5/1103 Detecting eye twinkling
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/6803 Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

An apparatus and method of collecting elements of and assembling various portions of ocular micro motions such as ocular micro-tremor (OMT) movements of the eye, and correlating them directly with OMT waveforms acquired from both known and unknown states of cognition and cognitive function. Comparing newly acquired waveforms from patients with undiagnosed cognitive dysfunctions, permits an individual or caregiver the ability to identify those unknown issues or cognitive states based on matching or relating statistically elements of their waveform with categories of other known cognitive processing normals and abnormals, functional and dysfunctional individuals. It also allows for measuring the effects of therapeutic agents (psychological or pharmacological) by relating them to measurable changes in cognitive function as a result of correlated changes in waveforms.

Claims

1. A system for diagnosing Attention Deficit Hyperactivity Disorder (ADHD) in a patient, comprising:

a signal acquisition subsystem including a sensor for obtaining an ocular autonomic micro-tremor signal;

a signal processing subsystem for creating an ocular autonomic waveform signature from the acquired ocular autonomic micro-tremor signal;

a subsystem for accessing an ADHD reference library of ocular autonomic waveform signatures collected and measured from a plurality of previously diagnosed ADHD patients, wherein the signal acquisition subsystem creates the ADHD reference library by obtaining an ocular autonomic micro tremor signal from the plurality of previously diagnosed ADHD patients and the signal processing subsystem creates ocular autonomic waveform signatures from the acquired ocular autonomic micro-tremor signals of the plurality of previously diagnosed ADHD patients; and

a correlation subsystem for comparing and correlating the patient'"'"'s ocular autonomic waveform signature with the waveform signatures of the plurality of previously diagnosed ADHD patients in the ADHD reference library, whereby a match between the patient'"'"'s ocular autonomic waveform signature and the waveform signatures of the previously diagnosed ADHD patients in the ADHD reference library provides a diagnosis of ADHD.

2. The system for diagnosing ADHD in the patient of claim 1, wherein the signal acquisition subsystem sensor is chosen from the group consisting of an optical sensor, a piezoelectric sensor, a strain gauge sensor, an accelerometer (sensor), a CW emitter/sensor, a pulsed light wave emitter sensor, and a sonic wave emitter/sensor, for discerning and measuring the autonomic micro motions and autonomic micro-tremors of the eye.

3. The system for diagnosing ADHD in the patient of claim 1, wherein the ocular autonomic waveform signature includes measuring and defining one or more parameters selected from the group consisting of:

leading edge rise time slopes and trailing edge fall times slopes of repetitive sinusoidal components of the optical autonomic micro-tremor signal waveforms;

midpoint and half-widths of repetitive sinusoidal components of the optical autonomic micro-tremor signal waveforms;

separations between peak intervals;

frequency of burst packages and waveform frequency of bursts and sinusoidal components;

spindle associated with the waveforms;

average and mean frequency of the waveform;

time intervals between voids between the optical autonomic micro-tremor signal packets; and

analyzing the mean amplitudes and extremes of the sinusoidal patterns and the collective bursts.

4. The system for diagnosing ADHD in the patient of claim 3, wherein transforms such as Fourier transforms are performed on the patient'"'"'s ocular autonomic waveform signature.

5. The system for diagnosing ADHD in the patient of claim 1, further comprising a subsystem for generating a normal reference library of ocular micro-tremor waveforms signatures collected and measured from a plurality of cognitively normal patients, wherein the signal acquisition subsystem creates the normal reference library by obtaining an ocular autonomic micro tremor signal from the plurality of cognitively normal patients and the signal processing subsystem creates ocular autonomic waveform signatures from the acquired ocular autonomic micro-tremor signals of the plurality of cognitively normal patients without attention deficit diagnoses or other cognitive dysfunctions.

6. The system for diagnosing ADHD in the patient of claim 5, wherein the patient is diagnosed as cognitive dysfunctional when the patient'"'"'s ocular autonomic waveform signature does not correlate with the normal reference library.

7. The system for diagnosing ADHD in the patient of claim 6, wherein the patient'"'"'s ocular autonomic waveform signature is compared and contrasted to the normal reference library, a cognitive dysfunctional library and other categorized libraries of cognitive dysfunctional classes, including an ADD library and an ADHD library.

8. The system for diagnosing ADHD in the patient of claim 5, wherein the correlation subsystem is applied to the diagnosed ADHD patient both before onset of therapeutic interventions, and post therapy to compare and contrast benefits of given therapies toward producing ocular autonomic micro-tremor signatures more typically similar to those of cognitive normal populations represented by the normal reference library.

9. The system for diagnosing ADHD in the patient of claim 1, wherein the ocular autonomic micro tremor signals have an average frequency between:

a lower limit of approximately 30 Hz; and

an upper limit of approximately 100 Hz.

10. The system for diagnosing ADHD in the patient of claim 1, wherein the ocular autonomic micro tremor signals have an average amplitude between:

a lower limit of approximately 150 nm; and

an upper limit of approximately 2500 nm.