Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
First Claim
Patent Images
1. An implant for treating a degenerative intervertebral disc which includes an annulus fibrosus and a nuclear cavity whose boundary is bordered by surrounding walls of the annulus fibrosus and by superior and inferior vertebrae, said implant comprising:
- an expandable porous pouch having an exterior surface and a size and shape, when in a collapsed state, to facilitate its insertion through an opening in the annulus fibrosus of the intervertebral disc and its introduction into the nuclear cavity of the intervertebral disc; and
a plurality of substantially demineralized bone units that are sized and shaped for insertion into said porous pouch, said porous pouch being expandable from said collapsed state to an expanded state, in which said exterior surface of said porous pouch engages a substantial portion of the boundary of the nuclear cavity of the intervertebral disc responsive to the insertion of said bone units into said porous pouch, and said bone units being non-osteoinductive as a result of having been soaked in hydrogen peroxide, whereby said bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth.
8 Assignments
0 Petitions
Accused Products
Abstract
A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0 mm to about 4.0 mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.
245 Citations
62 Claims
-
1. An implant for treating a degenerative intervertebral disc which includes an annulus fibrosus and a nuclear cavity whose boundary is bordered by surrounding walls of the annulus fibrosus and by superior and inferior vertebrae, said implant comprising:
-
an expandable porous pouch having an exterior surface and a size and shape, when in a collapsed state, to facilitate its insertion through an opening in the annulus fibrosus of the intervertebral disc and its introduction into the nuclear cavity of the intervertebral disc; and a plurality of substantially demineralized bone units that are sized and shaped for insertion into said porous pouch, said porous pouch being expandable from said collapsed state to an expanded state, in which said exterior surface of said porous pouch engages a substantial portion of the boundary of the nuclear cavity of the intervertebral disc responsive to the insertion of said bone units into said porous pouch, and said bone units being non-osteoinductive as a result of having been soaked in hydrogen peroxide, whereby said bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
-
-
41. A method of treating a degenerative intervertebral disc which includes an annulus fibrosus and a nuclear cavity whose boundary is bordered by surrounding walls of the annulus fibrosus and by superior and inferior vertebrae, the method comprising the steps of:
-
visualizing the nuclear cavity, wherein said visualizing step includes inserting a balloon into the nuclear cavity, filling the balloon with radio contrast fluid to a specified pressure such that the nuclear cavity is visible under fluoroscopy, and removing the balloon from the nuclear cavity; inserting an expandable porous pouch through the annulus fibrosus and into the nuclear cavity; and expanding the porous pouch by filling it with a plurality of substantially demineralized bone units until an exterior surface of the porous pouch engages a substantial portion of the boundary of the nuclear cavity of the intervertebral disc, the bone units being non-osteoinductive, whereby the bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth. - View Dependent Claims (42, 43)
-
-
44. A method of treating a degenerative intervertebral disc which includes an annulus fibrosus and a nuclear cavity whose boundary is bordered by surrounding walls of the annulus fibrosus and by superior and inferior vertebrae, the method comprising the steps of:
-
inserting an expandable porous pouch through the annulus fibrosus and into the nuclear cavity; deploying the porous pouch, wherein said deploying step includes placing a balloon into the inserted porous pouch, filling the balloon, and removing the balloon from the porous pouch; and expanding the porous pouch by filling it with a plurality of substantially demineralized bone units until an exterior surface of the porous pouch engages a substantial portion of the boundary of the nuclear cavity of the intervertebral disc, the bone units being non-osteoinductive, whereby the bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth; said deploying step being performed after said inserting step and before said expanding step. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53)
-
-
54. A method of treating a degenerative intervertebral disc which includes an annulus fibrosus and a nuclear cavity whose boundary is bordered by surrounding walls of the annulus fibrosus and by superior and inferior vertebrae, the method comprising the steps of:
-
inserting an expandable porous pouch through the annulus fibrosus and into the nuclear cavity; loading at least some of a plurality of substantially demineralized bone units into a plurality of tubes; and expanding the porous pouch by delivering the bone units from the plurality of tubes into the porous pouch and filling the porous pouch with the bone units from the plurality of tubes until an exterior surface of the porous pouch engages a substantial portion of the boundary of the nuclear cavity of the intervertebral disc, the bone units being non-osteoinductive, whereby the bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth. - View Dependent Claims (55)
-
-
56. A method of treating a degenerative intervertebral disc which includes an annulus fibrosus and a nuclear cavity whose boundary is bordered by surrounding walls of the annulus fibrosus and by superior and inferior vertebrae, the method comprising the steps of:
-
inserting an expandable porous pouch through the annulus fibrosus and into the nuclear cavity; lyophilizing a plurality of substantially demineralized bone units; weighing a quantity of the lyophilized bone units; hydrating the quantity of lyophilized bone units in fluid; loading at least some of the quantity of lyophilized bone units into at least one tube; and expanding the porous pouch by delivering the bone units from the at least one tube into the porous pouch and filling the porous pouch with the bone units from the at least one tube until an exterior surface of the porous pouch engages a substantial portion of the boundary of the nuclear cavity of the intervertebral disc, the bone units being non-osteoinductive, whereby the bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth, said lyophilizing, weighing and hydrating steps being performed before said loading step.
-
-
57. An implant for repair of a degenerative intervertebral disc which is bordered by a patient'"'"'s superior and inferior vertebrae, said implant comprising a porous pouch and a plurality of bone units that are sized and shaped for insertion into said porous pouch, said bone units being formed by a method including the steps of:
-
(a) demineralizing a sheet of bone; (b) treating the demineralized bone sheet to render it non-osteoinductive; and (c) cutting the demineralized, non-osteoinductive bone sheet into said bone units, whereby said bone units do not promote fusion of the superior and inferior vertebrae and do not promote bony ingrowth. - View Dependent Claims (58, 59, 60, 61, 62)
-
Specification