Solvating system and sealant for medical use in the middle or inner ear
First Claim
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1. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
- a) applying an aqueous solvating system comprising a metal ion sequestering agent and greater than 0.2 wt. % surfactant to a treatment site comprising a bacterial biofilm comprising an extracellular polysaccharide matrix attached or adhered to at least a portion of the middle or inner ear,b) detaching, removing or otherwise disrupting at least a part of the biofilm by solvating the extracellular polysaccharide matrix with the solvating system and then rinsing away the solvating system, and thenc) applying to the treatment site a protective layer of a polymeric film-forming sealant.
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Abstract
Chronic Otitis Media with Effusion (COME), Recurrent Acute Otitis Media (RAOM), cholesteatoma, and other bacterial ear conditions may be treated by applying a solvating system containing greater than 0.2 wt. % surfactant to a bacterial biofilm in the middle or inner ear, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.
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Citations
33 Claims
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1. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
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a) applying an aqueous solvating system comprising a metal ion sequestering agent and greater than 0.2 wt. % surfactant to a treatment site comprising a bacterial biofilm comprising an extracellular polysaccharide matrix attached or adhered to at least a portion of the middle or inner ear, b) detaching, removing or otherwise disrupting at least a part of the biofilm by solvating the extracellular polysaccharide matrix with the solvating system and then rinsing away the solvating system, and then c) applying to the treatment site a protective layer of a polymeric film-forming sealant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification