Microfabricated compositions and processes for engineering tissues containing multiple cell types
First Claim
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1. A three-dimensional system comprising at least two layers, wherein each layer comprises channels divided longitudinally into two compartments by a centrally positioned membrane, wherein each compartment includes a different cell type, and wherein the membrane has pores sized to enable fluid communication between the compartments while substantially preventing the passage of cells.
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Abstract
The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
63 Citations
37 Claims
- 1. A three-dimensional system comprising at least two layers, wherein each layer comprises channels divided longitudinally into two compartments by a centrally positioned membrane, wherein each compartment includes a different cell type, and wherein the membrane has pores sized to enable fluid communication between the compartments while substantially preventing the passage of cells.
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34. A device comprising a three-dimensional system of at least two layers, wherein each layer comprises channels divided longitudinally into two compartments by a centrally positioned membrane, wherein each compartment includes a different cell type, and wherein the membrane has pores sized to enable fluid communication between the compartments while substantially preventing the passage of cells;
- and a pumping means for circulating fluid through the device.
- View Dependent Claims (35, 36)
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37. A three-dimensional system comprising at least two layers, wherein each layer comprises channels divided longitudinally into two compartments by a centrally positioned membrane, wherein each compartment comprises a different cell type, and wherein at least one channel comprises parenchymal cells in one compartment and vasculature in the other compartment.
Specification