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Methods and compositions involving miRNA and miRNA inhibitor molecules

  • US 7,960,359 B2
  • Filed: 08/10/2007
  • Issued: 06/14/2011
  • Est. Priority Date: 11/12/2004
  • Status: Expired due to Fees
First Claim
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1. A method for reducing cell viability of human cancer cells comprising providing miRNA function to the cells by introducing into the cells a synthetic double-stranded RNA molecule 22-30 residues in length comprising:

  • a) an active strand comprising a sequence identical to human miR-34a andb) a separate complementary strand comprising a sequence that is 100% complementary to the human miR-34a sequence and at least one chemical modification at the 5′

    end that enhances uptake of the active strand,wherein the human cancer cells are lung cancer cells, cancerous T cells, prostate cancer cells, or skin cancer cells.

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