Cardiac pacing system, blood pressure regulating system, and cardiac disease treatment system by substituting native biological regulatory function

• US 7,962,216 B2
• Filed: 04/16/2008
• Issued: 06/14/2011
• Est. Priority Date: 08/05/2002
• Status: Active Grant

• Current Assignee: Fujikin Incorporated, National Cerebral And Cardiovascular Center
• Original Assignee: Fujikin Incorporated, National Cerebral And Cardiovascular Center
• Inventors: Sato, Takayuki, Sugimachi, Masaru, Sunagawa, Kenji
• Primary Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US12/103,786
• Publication Number:
  US 20080215107A1
• Time in Patent Office: 1,154 Days
• Field of Search: 607/44
• US Class Current: 607/44
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, analyzing, and processing the biological activity signals from the biological activity sensing means, calculating an organism stimulation signal, and outputting the organism stimulation signal, and organism stimulating means for receiving the organism stimulation signal calculated by the calculating means and stimulating an organism according to the organism stimulation signal. A cardiac pacing system based on the treating system, a blood pressure regulating system, and a cardiac disease treating system are also disclosed.

Claims

1. A system to treat cardiac diseases based on biological activities, comprising:

a) at least one cardiovascular activity sensing means which senses cardiovascular activity information issued by a cardiovascular system, and outputs a plurality of input cardiovascular activity signals;

b) a calculating means which receives the input cardiovascular activity signals, calculates a transfer function by computing a Fourier transform of normal cardiovascular activity signals and normal nerve activity signals from a normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a plurality of nerve stimulation signals for stimulation of a nerve using a convolution integral between the input cardiovascular activity signals and the impulse response, and outputs the nerve stimulation signals for stimulation of the nerve; and

c) a nerve stimulating means which receives the nerve stimulation signals, and stimulates the nerve based on the nerve stimulation signals.

2. The system of claim 1, wherein the nerve stimulating means is selected from the group consisting of electrical stimulation means and drug stimulation means.

3. The system of claim 1, wherein the calculating means comprises at least one amplifier to amplify the input cardiovascular activity signals.

4. A method of treating cardiac diseases based on biological activities, comprising the steps of:

a) calculating a transfer function by computing a Fourier transform of normal cardiovascular activity biosignals and normal nerve activity signals from a normal cardiovascular system and calculating at least one impulse response by computing an inverse Fourier transform of the transfer function;

b) sensing cardiovascular activity information issued by a cardiovascular system, and outputting a plurality of input cardiovascular activity signals based on the cardiovascular activity information;

c) calculating a plurality of nerve stimulation signals for stimulation of a nerve using a convolution integral between the impulse response and the input cardiovascular activity signals, comprising the substep of discriminating whether the input cardiovascular activity signals are caused by normal cardiovascular activities or by abnormal cardiovascular activities; and

d) outputting the nerve stimulation signals for stimulation of the nerve only if the input cardiovascular activity signals are determined to be caused by abnormal cardiovascular activities.

5. The method of claim 4, further comprising, after step d), the steps of:

e) receiving the nerve stimulation signals output in step d); and

f) stimulating the nerve based on the never stimulation signals output in step d).

6. The method of claim 5, wherein stimulating the nerve is selected from the group consisting of electrically stimulating the nerve and stimulating the nerve with drug stimulating means.

7. The method of claim 4, wherein calculating comprises amplifying the input cardiovascular activity signals.