Compensation reduction in tissue stimulation therapy
First Claim
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1. A method of treating a patient, comprising:
- delivering an electrical signal to a nerve according to a first setting of an on-time and off-time that defines a duty cycle, wherein said on-time defines the time during which an electrical burst of pluses occurs and said off-time defines the time with no electrical burst of pulses; and
automatically changing said first setting to a second setting of on-time and off-time in response to a physiological event, wherein said second setting defines a duty cycle substantially equal to the duty cycle defined by said first setting;
wherein said second setting is different from said first setting.
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Abstract
Methods and systems for reducing compensation of the body to therapy delivered by an implanted medical device are described herein. The disclosed techniques cause a change from one therapy protocol to another therapy protocol based on the occurrence of an event (e.g., time, user activations of a sensor, input from a physiological sensor, etc.). The therapy protocols of the implanted medical device differ in terms of the on-time and off-time, but effectuate the same or similar duty cycle.
478 Citations
18 Claims
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1. A method of treating a patient, comprising:
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delivering an electrical signal to a nerve according to a first setting of an on-time and off-time that defines a duty cycle, wherein said on-time defines the time during which an electrical burst of pluses occurs and said off-time defines the time with no electrical burst of pulses; and automatically changing said first setting to a second setting of on-time and off-time in response to a physiological event, wherein said second setting defines a duty cycle substantially equal to the duty cycle defined by said first setting; wherein said second setting is different from said first setting. - View Dependent Claims (2, 3, 4, 5)
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6. A system, comprising:
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at least one electrode coupled to a nerve; a pulse generator coupled to said at least one electrode, wherein said pulse generator provides an electrical signal to a nerve using said at least one electrode; and
a controller coupled to said pulse generator, wherein said controller causes said pulse generator to deliver said electrical signal to a nerve according to a first setting of an on-time and off-time that defines a first duty cycle and, in response to a physiological event, causes a change from said first setting to a second setting of an on-time and off- time that defines a second duty cycle that is no more than 5% different from the first duty cycle;wherein said on-time defines the time during which an electrical burst of pulses occurs and said off-time defines the time with no electrical burst of pulses; wherein said second setting is different from said first setting. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A method of treating a patient having a medical condition, comprising:
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applying to a vagus nerve of the patient a first electrical signal defined by a first plurality of parameters comprising a first on-time and a first off-time defining a first duty cycle; determining the occurrence of a physiological event and, in response to said physiological event ceasing said step of applying said first electrical signal to said vagus nerve, and applying to said vagus nerve a second electrical signal defined by a second plurality of parameters comprising a second on-time and a second off-time defining a second duty cycle that differs from said first duty cycle by no more than 10%; wherein each of said first and second on=times defines a time during which an electrical burst of pulses occurs and each of said first and second off-times define a time with no electrical burst of pulses; wherein said second electrical signal is different from said first electrical signal. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification