Stent drug delivery system
First Claim
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1. An expandable intraluminal stent comprising:
- a main body portion having a first end, a second end and a flow passage defined therethrough, the main body portion being sized for intraluminal placement within a body passage and subsequent expansion for implantation, the stent further comprising at least two separate regions longitudinally adjacent each other on the length of the main body portion, a first powdered material which is sintered together to form first pores within a first region, the first region characterized by a first porosity and a first pore size, and a second powdered material which is sintered together to form second pores within a second region, the second region characterized by a second porosity and a second pore size, wherein the first powdered material is chemically different from the second powdered material;
wherein the first region does not contain the second powdered material, or the second region does not contain the first powdered material.
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Abstract
Expandable intraluminal stents are provided as well their method of manufacture. These stents are made of metal, the metal characterized by a desired porosity, with a drug compressed into the pores of the stent. The stents are formed by subjecting one or more powdered metals in a die cavity to a pressure treatment followed by a heat treatment. The metal may be cast directly in a stent-like form or cast into sheets or tubes from which the inventive stents are produced. The so-formed porous metal stent is then loaded with one or more drugs.
52 Citations
14 Claims
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1. An expandable intraluminal stent comprising:
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a main body portion having a first end, a second end and a flow passage defined therethrough, the main body portion being sized for intraluminal placement within a body passage and subsequent expansion for implantation, the stent further comprising at least two separate regions longitudinally adjacent each other on the length of the main body portion, a first powdered material which is sintered together to form first pores within a first region, the first region characterized by a first porosity and a first pore size, and a second powdered material which is sintered together to form second pores within a second region, the second region characterized by a second porosity and a second pore size, wherein the first powdered material is chemically different from the second powdered material; wherein the first region does not contain the second powdered material, or the second region does not contain the first powdered material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An expandable intraluminal stent comprising:
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a main body portion having a first end, a second end, and a flow passage defined therethrough, the main body portion being sized for intraluminal placement within a body passage and subsequent expansion for implantation, the stent further comprising at least two separate regions longitudinally adjacent each other on the length of the main body portion, the first region comprising first sintered particles which are bonded to one another to form the first region, and the second region comprising second sintered particles which are bonded to one another to form the second region, the first region characterized by a first porosity and a first pore size and the second region characterized by a second porosity and a second pore size, wherein the first particles comprise a chemically different material than the second particles and at least one of the at least two separate regions comprises a metal; wherein the first region does not contain the second sintered particles, or the second region does not contain the first sintered particles.
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Specification