Degradable polymeric implantable medical devices with a continuous phase and discrete phase
First Claim
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1. An implantable medical device comprising:
- a structural element, wherein the structural element includes;
a continuous phase comprising a first polymer;
a discrete phase within the continuous phase, wherein the discrete phase comprises a second polymer including discrete phase segments;
the second polymer further includes anchor segments that have the same or substantially the same chemical make up as the first polymer of the continuous phase, and at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase.
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Abstract
The invention provides an implantable medical device comprising: a structural element, wherein the structural element includes: a continuous phase comprising a first polymer; a discrete phase within the continuous phase, wherein the discrete phase has a second polymer including discrete phase segments; and anchor segments that have substantially the same chemical make up as the first polymer of the continuous phase; wherein at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase.
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Citations
53 Claims
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1. An implantable medical device comprising:
a structural element, wherein the structural element includes; a continuous phase comprising a first polymer; a discrete phase within the continuous phase, wherein the discrete phase comprises a second polymer including discrete phase segments; the second polymer further includes anchor segments that have the same or substantially the same chemical make up as the first polymer of the continuous phase, and at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable medical device, comprising a blend including:
a structural element having; about 60 to about 99 wt % of a first polymer, wherein the first polymer forms a continuous phase; and about 1 to about 40 wt % of a second polymer, the second polymer forming a discrete phase within the continuous phase, wherein the second polymer having a Tg below body temperature comprises discrete phase segments that degrade to acidic fragments, the second polymer also comprises anchor segments having the same or substantially the same chemical make up as the continuous phase, wherein the anchor segment has phase-separated out from the discrete phase into the continuous phase. - View Dependent Claims (15, 16, 17)
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18. An implantable medical device, comprising a blend including:
a structural element having; about 60 to about 99 wt % of a first polymer, wherein the first polymer forms a continuous phase; about 0.2 to about 5 wt % of a second polymer, the second polymer forming a discrete phase within the continuous phase, the second polymer comprising discrete phase segments and anchor segments, wherein anchor segments have the same or substantially the same chemical make up as the first polymer of the continuous phase and have phase-separated out from the discrete phase into the continuous phase; and about 1 to about 40 wt % of a third polymer having a Tg below body temperature consists essentially of discrete phase segments, wherein the third polymer degrades into fragments at least some of which are acidic. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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25. A composition comprising:
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a continuous phase comprising a first polymer; a discrete phase within the continuous phase, wherein the discrete phase comprises a second polymer including discrete phase segments; the second polymer further includes anchor segments that have the same or substantially the same chemical make up as the first polymer of the continuous phase, and at least some of the anchor segments have partially or completely phase-separated from the discrete phase into the continuous phase. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method of forming a copolymer comprising:
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mixing glycolide monomers, caprolactone monomers, and a solvent to form a solution, wherein the glycolide and caprolactone monomers react in the solution to form poly(glycolide-co-ε
-caprolactone); andadding L-lactide monomers to allow L-lactide monomers to react with poly(glycolide-co-caprolactone) to form poly(glycolide-co-ε
-caprolactone)-b-poly(L-lactide).
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37. A method of forming a copolymer comprising:
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mixing glycolide monomers, caprolactone monomers, and a solvent to form a solution, wherein the glycolide monomers and caprolactone monomers react in the solution to form poly(glycolide-co-ε
-caprolactone);adding L-lactide monomers to allow L-lactide monomers to react with the poly(glycolide-co-ε
-caprolactone) to form poly(glycolide-co-ε
-caprolactone)-b-poly(L-lactide); andadding L-lactide and glycolide monomers to allow the L-lactide and glycolide monomers to react to form poly(glycolide-co-ε
-caprolactone)-b-poly(L-lactide-co-glycolide). - View Dependent Claims (38, 39, 40, 41, 42, 43)
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44. A method of forming a copolymer comprising:
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mixing L-lactide monomers with a solvent to form a solution, wherein L-lactide polymerizes to form poly(L-lactide); adding glycolide monomers and caprolactone monomers with the poly(L-lactide) to allow the glycolide monomers and caprolactone monomers to react with the poly(L-lactide) to form poly(L-lactide)-b-poly(glycolide-co-ε
-caprolactone). - View Dependent Claims (45, 46, 47, 48, 49, 50)
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51. A copolymer comprising poly(L-lactide)-b-poly(glycolide-co-ε
- -caprolactone).
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52. A copolymer comprising poly(glycolide-co-ε
- -caprolactone)-b-poly(L-lactide).
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53. A copolymer comprising poly(glycolide-co-ε
- -caprolactone)-b-poly(lactide-co-glycolide).
Specification