Platelet preservation composition containing eptifibatide, a reversible factor IIa inhibitor and a hemoglobin oxygen carrier
First Claim
Patent Images
1. A platelet preservation composition, comprising:
- a) a single antiplatelet agent;
b) an anticoagulant that reversibly inhibits factor IIa; and
c) a hemoglobin-based oxygen carrier at a concentration range of 1-18 gm/dl;
wherein said antiplatelet agent is eptifibatide and said composition is capable of extending the shelf-life of a platelet.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
26 Citations
7 Claims
-
1. A platelet preservation composition, comprising:
-
a) a single antiplatelet agent; b) an anticoagulant that reversibly inhibits factor IIa; and c) a hemoglobin-based oxygen carrier at a concentration range of 1-18 gm/dl; wherein said antiplatelet agent is eptifibatide and said composition is capable of extending the shelf-life of a platelet. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
Specification