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Variant form of urate oxidase and use thereof

  • US 7,964,381 B2
  • Filed: 09/10/2010
  • Issued: 06/21/2011
  • Est. Priority Date: 04/11/2005
  • Status: Active Grant
First Claim
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1. An isolated nucleic acid comprising a nucleic acid sequence which encodes a uricase selected from the group consisting of:

  • a uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 7;

    a uricase comprising the amino acid sequence of SEQ ID NO. 8;

    a uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 7 further comprising an amino terminal amino acid, wherein the amino terminal amino acid is alanine, glycine, proline, serine, or threonine; and

    the uricase comprising the amino acid sequence of position 8 through position 287 of SEQ ID NO. 7 further comprising an amino terminal amino acid, wherein the amino terminal amino acid is methionine.

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