Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method

• US 7,966,051 B2
• Filed: 01/09/2006
• Issued: 06/21/2011
• Est. Priority Date: 01/11/2005
• Status: Active Grant

• Current Assignee: Olympus Corporation
• Original Assignee: Olympus Corporation
• Inventors: Xie, Tianyu, Okawa, Atsushi
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Campbell; Victoria P
• Application Number:
  US11/327,866
• Publication Number:
  US 20060188402A1
• Time in Patent Office: 1,989 Days
• Field of Search: 600/431, 600/436, 600473-478, 600/317, 604/65, 604/66, 604/118, 604135-155
• US Class Current: 600/317
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence

Abstract

A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 26 to compare the detection result from the detection processing circuit with an analytical pattern stored in a pattern storage portion and calculate the peak time of the accumulation concentration in a tissue of a sample in the test bottle.

Claims

1. A fluorescent agent concentration measuring method comprising:

a fluorescence detection step of detecting fluorescence from a sample containing a body fluid taken from a living body administered with a fluorescent drug;

a fluorescent agent concentration calculation step of calculating the concentration of the drug in the living body, based on a detection signal from the fluorescence detection step; and

a peak time estimation step of estimating the peak time after administration of the drug into the living body, when the concentration of the drug in the living body tissue is the highest, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug.

2. A dose control method comprising:

a fluorescence detection step of detecting fluorescence from a sample containing a body fluid taken from a living body administered with a fluorescent drug;

a fluorescent agent concentration calculation step of calculating the concentration of the drug in the living body, based on a detection signal from the fluorescence detection step;

a peak time estimation step of estimating the time after administration of the drug into the living body, when the concentration of the drug in the living body tissue is the highest, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug;

an administration start judgment step of judging whether a predetermined time has elapsed or not and judging the start of administration of the drug when the predetermined time has elapsed;

a dose setting step of setting at least one of the dose and the administration time of the drug, based on the predetermined dose information of the drug after the judgment of the start of administration in the administration start judgment step; and

an output step of performing at least one of functions of allowing the dose to be displayed and allowing the drug to be administered automatically, based on the dose of the drug set in the dose setting step.