Analyte sensors and methods
First Claim
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1. A method for determining the concentration of ketone bodies in a sample, the method comprising:
- applying a sample to an analyte sensor, wherein the analyte sensor comprises a working electrode and a counter electrode;
applying a current to the working electrode and counter electrode;
measuring a predetermined amount of a current decay for the current;
predicting a first total signal value for complete reaction of the analyte from the measured current decay;
determining a data collection endpoint, wherein the data collection endpoint is a predetermined percentage of the predicted first total signal value;
measuring current decay until the data collection endpoint;
calculating a second total signal value at the data collection endpoint; and
determining the concentration of ketone bodies based on the calculated second total signal value and the measured current decay until the data collection endpoint.
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Abstract
Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.
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Citations
8 Claims
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1. A method for determining the concentration of ketone bodies in a sample, the method comprising:
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applying a sample to an analyte sensor, wherein the analyte sensor comprises a working electrode and a counter electrode; applying a current to the working electrode and counter electrode; measuring a predetermined amount of a current decay for the current; predicting a first total signal value for complete reaction of the analyte from the measured current decay; determining a data collection endpoint, wherein the data collection endpoint is a predetermined percentage of the predicted first total signal value; measuring current decay until the data collection endpoint; calculating a second total signal value at the data collection endpoint; and determining the concentration of ketone bodies based on the calculated second total signal value and the measured current decay until the data collection endpoint. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification