Injector for viscous materials

• US 7,967,772 B2
• Filed: 01/12/2005
• Issued: 06/28/2011
• Est. Priority Date: 01/12/2004
• Status: Active Grant

• Current Assignee: Nova Eye Incorporated
• Original Assignee: iScience Interventional Corporation
• Inventors: McKenzie, John R., Kupiecki, David J., Conston, Stanley R.
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US10/585,909
• Publication Number:
  US 20070287958A1
• Time in Patent Office: 2,358 Days
• Field of Search: 604/890.1, 604 65- 67, 604/131, 604/19, 604/232, 604/240, 604/239, 604/234, 604200-206
• US Class Current: 604/19
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31586 performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
• CPC Class Codes: A61M 5/486 Indicating injection pressure

Abstract

An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.

Claims

1. A device for delivering microquantities of viscous materials comprising

an injector for delivery of viscous materials from a cartridge containing a prepackaged quantity of said viscous materials, said injector comprising a syringe body with a proximal end, a distal end with an outlet and a hollow bore between the ends sized and shaped to receive said cartridge;

an internal needle in communication with said outlet and internal to the distal end of said injector, said internal needle located for penetration of said cartridge;

and a plunger disposed within the hollow bore coupled to a positive displacement mechanism that progressively advances the plunger toward the distal end of the syringe body to eject the material within a cartridge in the hollow bore through said outlet; and

a microcannula or microcatheter attached to said outlet in communication with said needle.

2. A device according to claim 1 wherein said microquantities are in the range of about 5 to 25 microliters.

3. The device according to claim 1 wherein in said injector said positive displacement mechanism comprises a threaded rod attached to said plunger.

4. The device according to claim 3 wherein said threaded rod has a thread pitch greater than or equal to 40 threads per inch.

5. The device according to claim 1 wherein in said injector said positive displacement mechanism comprises a linear translation mechanism with a series of spaced mechanical stops.

6. The device according to claim 1 wherein in said injector said positive displacement mechanism is coupled to a powered source of motion.

7. The device according to claim 1 wherein in said injector said positive displacement mechanism provides a repeatable increment of delivered volume of material of less than about 25 microliters.

8. The device according to claim 1 wherein said injector additionally comprising means for regulation of the injection pressure.

9. The device according to claim 8 wherein said means for regulation of the injection pressure comprises an attenuator to limit the force applied to eject said material.

10. The device according to claim 9 wherein said attenuator comprises a clutch engageable to said positive displacement mechanism.

11. The device according to claim 1 wherein said injector additionally comprising an injector pressure monitor.

12. The device according to claim 11 wherein said monitor provides feedback information on pressure to an actuator, wherein said actuator provides power to drive said positive displacement mechanism.

13. The device according to claim 1 wherein said injector additionally comprises a pressure relief valve to relieve pressure within said hollow bore.

14. The device according to claim 1 wherein said injector further comprises an internal needle within said hollow bore for penetration of said cartridge to provide a flow path from within said cartridge to said outlet.

15. A kit for delivering microquantities of viscous materials comprising

an injector for delivery of viscous materials from a cartridge containing a prepackaged quantity of said viscous materials, said injector comprising a syringe body with a proximal end, a distal end with an outlet and a hollow bore between the ends sized and shaped to receive said cartridge;

an internal needle in communication with said outlet and internal to the distal end of said injector, said internal needle located for penetration of said cartridge;

and a plunger disposed within the hollow bore coupled to a positive displacement mechanism that progressively advances the plunger toward the distal end of the syringe body to eject the material within a cartridge in the hollow bore through said outlet; and

a microcannula or microcatheter adapted for attachment to said outlet in communication with said needle.

16. The kit according to claim 15 wherein said positive displacement mechanism comprises a threaded rod attached to said plunger having a thread pitch greater than or equal to 40 threads per inch.

17. The kit according to claim 15 wherein said positive displacement mechanism comprises a series of spaced mechanical stops for controlling the linear displacement of said plunger.

18. The kit according to claim 15 wherein in said injector said positive displacement mechanism provides a repeatable increment of delivered volume of material of less than about 25 microliters.

19. The kit according to claim 15 wherein in said injector said positive displacement mechanism is coupled to a powered source of motion.

20. The kit according to claim 15 wherein said injector additionally comprises a regulator of the injection pressure, said regulator comprising an attenuator to limit the force applied to eject said material.

21. The kit according to claim 20 wherein said attenuator comprises a clutch engageable to said positive displacement mechanism.

22. The kit according to claim 15 wherein said injector additionally comprises an injector pressure monitor to provide feedback information on pressure to an actuator, wherein said actuator provides power to drive said positive displacement mechanism.

23. The kit according to claim 15 wherein said injector additionally comprises a pressure relief valve to relieve pressure within said hollow bore.

24. The kit according to claim 15 comprising a plurality of microcannulae.

25. The kit according to claim 15 wherein said injector further comprises an internal needle within said hollow bore for penetration of said cartridge to provide a flow path from within said cartridge to said outlet.