Electromagnetic treatment of tissues and cells

• US 7,967,839 B2
• Filed: 03/31/2004
• Issued: 06/28/2011
• Est. Priority Date: 05/20/2002
• Status: Expired due to Fees

• Current Assignee: Rocky Mountain Biosystems, Inc.
• Original Assignee: Rocky Mountain Biosystems, Inc.
• Inventors: Marchitto, Kevin S., Flock, Stephen T.
• Primary Examiner(s): Johnson, III; Henry M
• Assistant Examiner(s): ROANE, AARON F
• Application Number:
  US10/815,084
• Publication Number:
  US 20040210282A1
• Time in Patent Office: 2,645 Days
• Field of Search: 607/96, 607 98-103, 606/32, 606/34, 606/41, 600/2, 600/8, 128/898
• US Class Current: 606/213
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/0487 Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks suture anchors A61B17/0401; wound clamps or clips A61B17/08; ligaturing clamps or clips A61B17/122
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/1114 of the digestive tract, e.g. bowels or oesophagus
• CPC Class Codes: A61B 17/115 Staplers for performing anastomosis in a single operation
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2017/0412 having anchoring barbs or pins extending outwardly from suture anchor body
• CPC Class Codes: A61B 2017/0427 having anchoring barbs or pins extending outwardly from the anchor body
• CPC Class Codes: A61B 2017/0443 the shaft being resilient and having a coiled or helical shape in the released state
• CPC Class Codes: A61B 2017/0456 Surface features on the anchor, e.g. ribs increasing friction between the suture and the anchor
• CPC Class Codes: A61B 2017/0462 One way system, i.e. also tensioning the suture
• CPC Class Codes: A61B 2017/0464 for soft tissue
• CPC Class Codes: A61B 2017/0488 Instruments for applying suture clamps, clips or locks for applying suture anchors A61B2017/0409; for applying wound clamps A61B17/10; for applying ligaturing clamps or clips A61B17/128
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/0649 Coils or spirals
• CPC Class Codes: A61B 2018/00619 Welding
• CPC Class Codes: A61L 27/50 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61N 1/40 : Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals
• CPC Class Codes: A61N 2/02 : using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Provided herein are methods, devices and compositions to conductively or to inductively fix substrates, including tissues, using electromagnetic energy. Also provided is a method of controlling the fixing process via feedback monitoring of a property of the composition and/or of the electromagnetic energy used.

Claims

1. A method of treatment for one or more substrates in an individual, comprising:

securing said substrate(s) proximal to a susceptor, wherein said substrate is intact and said susceptor is a dissociable ion, or a mixture of dissociable ions;

applying radiofrequency energy that generates a magnetic field to said substrate(s) or to said susceptor or to a combination thereof to inductively generate heat therein;

affixing said substrate(s) via said heat thereby effecting treatment; and

controlling the affixing of said substrate(s) via feedback monitoring of a property of said susceptor, said energy or a combination thereof.

2. The method of claim 1, wherein said substrate(s) is a tissue, an implant or a bandage.

3. The method of claim 1, wherein said substrate is secured by a surgical fastener, a laminate or a surgical fitting further comprised of a fusion composition.

4. The method of claim 3, wherein said surgical fastener is a staple, a clip or a suture.

5. The method of claim 1, wherein said substrate is secured by an adherend.

6. The method of claim 5, wherein said adherend is a protein or a polymer.

7. The method of claim 1, wherein said energy is applied in pulses.

8. The method of claim 1, wherein said radiofrequency energy has a frequency of about 20 kHz to about 40 GHz.

9. The method of claim 1, wherein said magnetic field is generated via a substantially flat antenna.

10. The method of claim 9, wherein said antenna comprises at least one coil of electrical conductor.

11. The method of claim 10, wherein said electrical conductor is a solid wire or hollow tubing.

12. The method of claim 9, wherein said antenna is a single coil antenna, or a double coil antenna.

13. The method of claim 1, wherein affixing said substrate(s) forms a scaffold or a lattice structure within said substrate or between substrates.

14. The method of claim 1, wherein affixing said substrate(s) seals a tissue, fills a tissue defect, or bonds tissues together.

15. The method of claim 1, wherein said property is heat, an electrical property, eddy currents, conductivity, or frequency changes or a combination thereof.

16. The method of claim 15, wherein heat is monitored via optical detection.

17. The method of claim 16, wherein said optical detection is infrared.