Lipids containing omega-3 and omega-6 fatty acids

• US 7,968,112 B2
• Filed: 10/15/2007
• Issued: 06/28/2011
• Est. Priority Date: 10/22/2003
• Status: Expired due to Fees

• Current Assignee: Enzymotec Limited (International Flavors & Fragrances Incorporated)
• Original Assignee: Enzymotec Limited (International Flavors & Fragrances Incorporated)
• Inventors: Bar-On, Zohar, Shulman, Avidor, Ben Dror, Gai, Plat, Dorit, Zuabi, Rassan, Pelled, Dori, Farkash, Orly
• Primary Examiner(s): Wax; Robert A
• Assistant Examiner(s): Sasan; Aradhana
• Application Number:
  US11/872,440
• Publication Number:
  US 20080085320A1
• Time in Patent Office: 1,352 Days
• Field of Search: 424/439, 424/523, 424/195.17
• US Class Current: 424/439
• CPC Class Codes: A21D 2/32 Phosphatides
• CPC Class Codes: A23D 7/013 Spread compositions
• CPC Class Codes: A23D 9/013 Other fatty acid esters, e.g. phosphatides
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2250/1842 Lecithin
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/1942 Long-chain triglycerides
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidyicholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.

Claims

1. A method of treating a subject suffering from a cognitive or mental condition or disorder which comprises administering to the subject a therapeutically effective amount of a preparation, comprising serine glycerophospholipids which comprise a non-mammalian derived mixture of serine glycerophospholipids comprising eicosapentaenoic acid (EPA) and serine glycerophospholipids comprising docosahexaenoic acid (DHA), wherein each such serine glycerophospholipid comprising EPA and each such serine glycerophospholipid comprising DHA has the formula (I):

2. The method according to claim 1, wherein said glycerophospholipid conjugate is prepared by enzymatic transphosphatidylation of a lipid source, preferably any one of plant, animal or microorganism source.

3. The method according to claim 1 wherein the preparation is present in a pharmaceutical composition.

4. The method according to claim 3, wherein the pharmaceutical composition further comprises at least one pharmaceutically acceptable additive, diluent or excipient.

5. The method according to claim 4, wherein the pharmaceutical composition further comprises at least one additional pharmaceutically active agent.

6. The method according to claim 3, wherein the pharmaceutical composition is delivered orally or intravenously.

7. The method according to claim 1 wherein the preparation is present in a nutraceutical composition.

8. The method according to claim 7, wherein said nutraceutical composition is in the form of a softgel capsule, tablet, syrup, or other dietary supplement delivery system.

9. The method according to claim 1 wherein the preparation is present in a functional food.

10. The method according to claim 9, wherein the functional food is a dairy product, ice-cream, biscuit, soy product, bakery, pastry, bread, sauce, soup, prepared food, frozen food, condiment, confectionary, oil, fat, margarine, spread, filling, cereal, instant product, drink, shake, infant formula, infant food, bar, snack, candy or chocolate product.